局部区域晚期口咽癌患者的海马保护容积调强弧形放疗
Hippocampus sparing volumetric modulated arc therapy in patients with loco-regionally advanced oropharyngeal cancer.
作者信息
Seol Seung Won, Lee Brian H, Sita Timothy L, Devineni Jay Ram, Kruser Tim J, Sachdev Sean, Gentile Michelle, Helenowski Irene, Mittal Bharat B
机构信息
Department of Radiation Oncology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Department of Preventive Medicine, Northwestern University Biostatistics Division, Chicago, IL, USA.
出版信息
Phys Imaging Radiat Oncol. 2022 Sep 24;24:71-75. doi: 10.1016/j.phro.2022.09.008. eCollection 2022 Oct.
This study aimed to assess the incidental radiation exposure of the hippocampus (HC) in locoregionally-advanced oropharyngeal cancer patients undergoing volumetric modulated arc therapy and the feasibility of HC-sparing plan optimization. The initial plans were generated without dose-volume constraints to the HC and were compared with the HC-sparing plans. The incidental D_median doses to the bilateral, ipsilateral and contralateral HC were 2.9, 3.1, and 2.5 Gy in the initial plans and 1.4, 1.6, and 1.3 Gy with HC-sparing. It was feasible to reduce the HC dose with HC-sparing plan optimization without compromising target coverage and/or dose constraints to other OARs.
本研究旨在评估接受容积调强弧形放疗的局部晚期口咽癌患者海马体（HC）的 incidental 辐射暴露情况以及优化海马体保护计划的可行性。初始计划在没有对海马体进行剂量体积限制的情况下生成，并与海马体保护计划进行比较。初始计划中双侧、同侧和对侧海马体的 incidental D_median 剂量分别为 2.9、3.1 和 2.5 Gy，而在海马体保护计划中分别为 1.4、1.6 和 1.3 Gy。通过优化海马体保护计划来降低海马体剂量是可行的，且不会影响靶区覆盖和/或对其他危及器官的剂量限制。
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