Mützel W, Taenzer V, Wolf R
Invest Radiol. 1976 Nov-Dec;11(6):598-601. doi: 10.1097/00004424-197611000-00018.
The biotransformation of the 131I-labeled cholegraphic media ioglycamic acid, iodoxamic acid and iotroxic acid in man is investigated. Plasma, urine and fistular bile were analyzed for unchanged and metabolized constituents of the administered substances using thin layer chromatography. No metabolites were found in plasma, but up to two were found in urine in addition to unchanged contrast media (a total of 50% of the total elimination in 24 hr. urine). A metabolite was only found in the fistular bile after the injection of iotroxic acid.
对131I标记的胆影葡胺、碘多啥酸和碘甲腺氨酸在人体中的生物转化进行了研究。采用薄层色谱法分析血浆、尿液和瘘管胆汁中所给药物质的未变化成分和代谢成分。血浆中未发现代谢物，但尿液中除未变化的造影剂外还发现了多达两种代谢物（在24小时尿液中的总消除量中占50%）。仅在注射碘甲腺氨酸后在瘘管胆汁中发现一种代谢物。
