MURRAY I M
J Exp Med. 1963 Jan 1;117(1):139-47. doi: 10.1084/jem.117.1.139.
Rats were injected intravenously with various particulate materials with and without the addition of various stabilizing agents. One hour after the injection of the blockading colloid, a tracer dose of similar or different colloidal material was injected. A half-time clearance rate of the tracer dose greater than 4 minutes was taken as evidence of blockade of the RES. Blockade of the tracer dose occurred when the surface properties of the particles in both blockading and tracer doses were identical. Different particles stabilized by the same agent behaved as identical particles and identical particles stabilized by different agents behaved as different particles. The opsonization of a tracer dose of gelatin-stabilized colloid in vitro by a specific globulin fraction obtained from heterologous and homologous plasma prevented its blockade, while opsonization of both blockading and tracer doses with the same proteins resulted in blockade. However, when both blockading and tracer doses were opsonized with isologous globulins, blockade did not occur.
给大鼠静脉注射各种颗粒物质，有的添加了各种稳定剂，有的未添加。在注射封闭性胶体1小时后，注射示踪剂量的相似或不同胶体物质。示踪剂量的半衰期清除率大于4分钟被视为网状内皮系统（RES）被封闭的证据。当封闭剂量和示踪剂量中的颗粒表面性质相同时，示踪剂量会被封闭。由相同试剂稳定的不同颗粒表现得如同相同颗粒，而由不同试剂稳定的相同颗粒表现得如同不同颗粒。从异种和同种血浆中获得的特定球蛋白组分在体外对示踪剂量的明胶稳定胶体进行调理作用可防止其被封闭，而用相同蛋白质对封闭剂量和示踪剂量都进行调理作用则会导致封闭。然而，当用同种球蛋白对封闭剂量和示踪剂量都进行调理作用时，不会发生封闭。
