Qiu D M
Beijing Hospital.
Zhonghua Jie He He Hu Xi Za Zhi. 1992 Feb;15(1):11-3, 60.
The capacity of IL-2 production of peripheral blood lymphocyte (PBL) were determined in 54 patients with pneumonia in acute stage (23 cases of 20-57 years old and 31 cases over 60 years old) and 33 cases in convalescent stage. 20 elderly COPD in remission patients and 59 healthy control (32 aged 20-55 and 27 over 60) were determined also. It was shown that the capacity of IL-2 production of the patients with pneumonia in acute stage were markedly lower than healthy control (P less than 0.01), and that of the elderly patients' were markedly lower than elderly COPD patients also (P less than 0.01). The IL-2 level were also lower in the patients with pneumonia in convalescence than in the healthy control (P less than 0.01). The capacity of IL-2 production of elderly COPD patients and healthy elderly donors were at the same level (P greater than 0.05), both of the two groups' IL-2 level were significantly lower than that of the healthy young-middle age donors. It was suggested that the lowered immune function may be one of the important factors causing the COPD patients and the elderly people susceptible to infection, and it may be one of the important causes of the more severe condition and protracted course in elderly patients.
测定了54例急性期肺炎患者（23例年龄在20 - 57岁，31例年龄超过60岁）、33例恢复期患者、20例缓解期老年慢性阻塞性肺疾病（COPD）患者以及59例健康对照者（32例年龄在20 - 55岁，27例年龄超过60岁）外周血淋巴细胞（PBL）产生白细胞介素 - 2（IL - 2）的能力。结果显示，急性期肺炎患者产生IL - 2的能力显著低于健康对照者（P < 0.01），老年患者产生IL - 2的能力也显著低于老年COPD患者（P < 0.01）。恢复期肺炎患者的IL - 2水平也低于健康对照者（P < 0.01）。老年COPD患者和健康老年供者产生IL - 2的能力处于同一水平（P > 0.05），两组的IL - 2水平均显著低于健康中青年供者。提示免疫功能降低可能是导致COPD患者和老年人易感染的重要因素之一，也可能是老年患者病情更严重、病程迁延的重要原因之一。
