Pozsonyi T, Jakab L, Jakab L, Onody K, Cseh K, Kalabay L
Semmelweis Orvostudományi Egyetem III., Budapest.
Orv Hetil. 1992 May 10;133(19):1167-71.
The mitogenic response of peripheral lymphocytes was investigated in 12 patients with systemic lupus erythematosus and in healthy female volunteers who were on 11 and without 9 contraceptive pills. The effect of estrogen (ethinyl-estradiol 10(-5)-10(-6)-10(-7)M) was studied on Phytohaemagglutinin and Pokeweed mitogen induced blastogenic transformation and interleukin-2 production of peripheral lymphocytes in vitro. We observed a significantly depressed Phytohaemagglutinin induced lymphoblastic transformation both in patients and women taking oral contraceptive in presence of 10(-5)M estrogen as compared to normal controls. However there was no significant alteration neither in the response of lymphocyte nor in the production of interleukin-2 using of Pokeweed mitogen. The stimulataneous inhibition of the interleukin-2 production proved to be moderate. Marked significant correlation (r greater than = 0.8) vas detected between lymphoblastic transformation and interleukin-2 production in healthy females. Correlation coefficient measured in females taking oral contraceptive (r less than = 0.64) and patients with systemic lupus erythematosus (r less than = 0.34) suggest that in these groups the inhibition of lymphoblastic transformation is due to the inhibition effect of estrogen on the interleukin-2 production.
对12例系统性红斑狼疮患者以及11名服用避孕药和9名未服用避孕药的健康女性志愿者的外周淋巴细胞有丝分裂反应进行了研究。研究了雌激素（炔雌醇10^(-5)-10^(-6)-10^(-7)M）对体外植物血凝素和商陆有丝分裂原诱导的外周淋巴细胞的致有丝分裂转化及白细胞介素-2产生的影响。我们观察到，与正常对照组相比，在存在10^(-5)M雌激素的情况下，患者和服用口服避孕药的女性中植物血凝素诱导的淋巴细胞转化均显著降低。然而，使用商陆有丝分裂原时，淋巴细胞反应和白细胞介素-2产生均无显著变化。白细胞介素-2产生的协同抑制作用被证明是中等程度的。在健康女性中，淋巴细胞转化与白细胞介素-2产生之间检测到显著的相关性（r≥0.8）。在服用口服避孕药的女性（r≤0.64）和系统性红斑狼疮患者（r≤0.34）中测量的相关系数表明，在这些组中，淋巴细胞转化的抑制是由于雌激素对白细胞介素-2产生的抑制作用。
