Duffy M J, Reilly D, Brouillet J P, McDermott E W, Faul C, O'Higgins N, Fennelly J J, Maudelonde T, Rochefort H
Department of Nuclear Medicine, St. Vincent's Hospital, Dublin, Ireland.
Clin Chem. 1992 Oct;38(10):2114-6.
Cathepsin D (CD) is an aspartyl protease implicated in cancer metastasis. In this study of 331 patients, we show that patients with primary breast carcinomas containing high concentrations of CD have a significantly shorter disease-free interval (chi-square = 4.28, P < 0.05) and overall survival (chi-square = 7.7, P < 0.01) than patients with low concentrations. CD as a prognostic marker for overall survival was equally valuable for women younger (chi-square = 4.39, P < 0.05) and older (chi-square = 3.97, P < 0.05) than 50 years. CD was also a significant prognostic marker for overall survival within the estradiol receptor (ER)-positive subgroup of patients (chi-square = 5.79, P < 0.025), but not in the ER-negative subgroup. Patients with tumors containing high concentrations of CD and low concentrations of ER had shorter disease-free intervals (chi-square = 15.1, P < 0.001) and lower overall survival (chi-square = 20.9, P < 0.001) than patients with high concentrations of ER but low concentrations of CD.
组织蛋白酶D（CD）是一种与癌症转移有关的天冬氨酰蛋白酶。在这项针对331名患者的研究中，我们发现，原发性乳腺癌中CD浓度高的患者与浓度低的患者相比，无病生存期显著缩短（卡方=4.28，P<0.05），总生存期也显著缩短（卡方=7.7，P<0.01）。CD作为总生存期的预后标志物，对于年龄小于50岁（卡方=4.39，P<0.05）和大于50岁（卡方=3.97，P<0.05）的女性同样有价值。在雌激素受体（ER）阳性的患者亚组中，CD也是总生存期的一个显著预后标志物（卡方=5.79，P<0.025），但在ER阴性亚组中不是。与ER浓度高但CD浓度低的患者相比，肿瘤中CD浓度高且ER浓度低的患者无病生存期更短（卡方=15.1，P<0.001），总生存期更低（卡方=20.9，P<0.001）。
