Joensuu H, Toikkanen S, Isola J
Department of Oncology and Radiotherapy, University of Turku, Finland.
Br J Cancer. 1995 Jan;71(1):155-9. doi: 10.1038/bjc.1995.32.
Breast cancers with an increased level of cathepsin D in tumour tissue extract have been found to have poor prognosis, but studies performed with immunohistochemistry have produced variable results. We analysed 213 primary invasive breast cancers for cathepsin D expression from archival tissue with immunohistochemistry. The minimum follow-up of the patients still alive was 26 years. Women with ductal cancer that lacked cathepsin D expression in stromal macrophage-like cells had a 75% 5 year and 55% 30 year survival rate as compared with only a 40% 5 year and 20% 30 year survival rate if stromal cells expressed cathepsin D (P = 0.0003), whereas cathepsin D expression of cancer cells was associated with neither survival nor the several prognostic factors investigated. Stromal cell cathepsin D was more often present in the ductal than in the lobular histological type (80% vs 54%, P = 0.002), and its expression was strongly associated particularly with a high cell proliferation rate. However, in a multivariate analysis stromal cell cathepsin D expression did not have independent influence on survival in the entire series. We conclude that high stromal cell cathepsin D expression is associated with a poor short- and long-term outcome in breast cancer.
已发现肿瘤组织提取物中组织蛋白酶D水平升高的乳腺癌预后较差，但采用免疫组织化学进行的研究结果却不尽相同。我们用免疫组织化学方法分析了存档组织中213例原发性浸润性乳腺癌的组织蛋白酶D表达情况。对仍存活患者的最短随访时间为26年。与基质细胞表达组织蛋白酶D时5年生存率仅为40%、30年生存率仅为20%相比，导管癌患者若基质巨噬细胞样细胞中缺乏组织蛋白酶D表达，其5年生存率为75%，30年生存率为55%（P = 0.0003），而癌细胞的组织蛋白酶D表达与生存率及所研究的几个预后因素均无关。基质细胞组织蛋白酶D在导管组织学类型中比在小叶组织学类型中更常见（80%对54%，P = 0.002），其表达尤其与高细胞增殖率密切相关。然而，在多变量分析中，基质细胞组织蛋白酶D表达对整个系列患者的生存率并无独立影响。我们得出结论，基质细胞组织蛋白酶D高表达与乳腺癌的短期和长期不良预后相关。
