Granata G, Coradini D, Cappelletti V, Di Fronzo G
Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy.
Eur J Cancer. 1991;27(8):970-2. doi: 10.1016/0277-5379(91)90260-k.
The concentration of total cathepsin D in cytosols of 199 node negative women with primary breast cancer in a 10-year retrospective cohort was assayed. Cathepsin D status alone was unable to predict disease-free or overall survival. However, those patients with receptor positive tumours who were cathepsin D positive had shorter [corrected] disease-free (P = 0.02) and overall survival (P = 0.01) than cathepsin D negative patients. Therefore, measurement of cathepsin D appears to provide additional prognostic information for the prediction of disease-free and overall survival in patients with node negative breast cancer.
在一项为期10年的回顾性队列研究中，对199例原发性乳腺癌淋巴结阴性女性的细胞溶质中组织蛋白酶D的总浓度进行了测定。仅组织蛋白酶D状态无法预测无病生存期或总生存期。然而，那些肿瘤受体阳性且组织蛋白酶D呈阳性的患者，其校正后的无病生存期（P = 0.02）和总生存期（P = 0.01）比组织蛋白酶D阴性的患者短。因此，测定组织蛋白酶D似乎为预测淋巴结阴性乳腺癌患者的无病生存期和总生存期提供了额外的预后信息。
