Lye M D, Ritch A E
Rheumatol Rehabil. 1977 Feb;16(1):62-9. doi: 10.1093/rheumatology/16.1.62.
Anabolic steroids have been widely recommended in the management of debility in association with the diseases of old age. Their action in promoting weight gain and in speeding rehabilitation is said to depend on nitrogen retention leading to increased muscle bulk reflected by increased fat-free mass (lean-body mass). In elderly patients undergoing rehabilitation a double-blind trial over 4 months of stanozolol, an orally active anabolic agent, is reported in which measurements of total body weight, body fat and fat-free mass were recorded. Physical activity and performance levels were also measured. Total body weight was found to have increased in both groups of patients, mainly due to increased body fat. There was no evidence of fluid retention due to the drug. Despite the absence of an anabolic effect, the group taking stanozolol increased their levels of physical activity significantly.
合成代谢类固醇已被广泛推荐用于治疗与老年疾病相关的虚弱症。据说它们促进体重增加和加速康复的作用取决于氮潴留，从而导致肌肉量增加，这表现为去脂体重（瘦体重）增加。据报道，在接受康复治疗的老年患者中，进行了一项为期4个月的司坦唑醇双盲试验，司坦唑醇是一种口服活性合成代谢药物，试验记录了总体重、体脂和去脂体重的测量值。还测量了身体活动和机能水平。发现两组患者的总体重均有所增加，主要是由于体脂增加。没有证据表明该药物导致液体潴留。尽管没有合成代谢作用，但服用司坦唑醇的组身体活动水平显著提高。
