Higgins P M
Epidemiol Infect. 1992 Oct;109(2):199-209. doi: 10.1017/s0950268800050160.
Over a period of 9 years in general practice temporary enlargement of the spleen was found in 29 episodes of pharyngitis or tonsillitis, in 2 episodes of acute upper respiratory tract infection other than pharyngitis and in 6 episodes of acute cervical lymphadenitis. In five patients more than one episode of illness associated with splenomegaly was recorded. In 26 of the 37 episodes a possible aetiology was identified. Evidence only of infection with group A streptococci was found in 14 episodes, adenoviruses or coxsackie B viruses were isolated alone in 4 episodes and in 4 episodes the only finding was the presence in the blood of more than occasional atypical mononuclear cells; in 4 episodes there was evidence of both streptococcal and viral infection. Episodes with evidence of streptococcal infection only tended to be of shorter duration and to be more evenly distributed over the year than were episodes without such evidence. Temporary splenomegaly was noted also in two children with varicella (one of whom also had streptococcal infection) and in an adult with probable rubella.
在9年的全科医疗实践中，发现29例咽炎或扁桃体炎、2例非咽炎的急性上呼吸道感染以及6例急性颈淋巴结炎出现脾脏暂时肿大。5名患者记录了不止一次与脾肿大相关的疾病发作。在37例发作中的26例中确定了可能的病因。仅在14例中发现A组链球菌感染的证据，4例单独分离出腺病毒或柯萨奇B病毒，4例唯一的发现是血液中偶尔出现的非典型单核细胞增多；4例有链球菌和病毒感染的证据。仅出现链球菌感染证据的发作往往持续时间较短，且比无此类证据的发作在一年中分布更均匀。两名水痘患儿（其中一名也有链球菌感染）和一名可能患风疹的成年人也出现了暂时脾肿大。
