Eskelinen A, Santalahti J
Department for Dermatological Research, ARS-Medicina, Helsinki, Finland.
J Int Med Res. 1992 Jun;20(3):227-33. doi: 10.1177/030006059202000304.
Evidence is accumulating that cartilage polysaccharides derived from marine fish have a repairing effect on solar elastosis. In a double-blind trial, the efficacy and safety of two commercial preparations, Vivida and Imedeen, were compared in the treatment of sun-damaged skin in women aged 40-60 years. A group of 15 women received 500 mg/day Vivida and another 15 women received 380 mg/day Imedeen orally for 90 days. Subjective assessment revealed statistically significant improvements in skin condition in both treatment groups but Vivida was significantly (P less than 0.01) more effective than Imedeen for all parameters. In the Vivida group, mean epidermal thickness increased from 0.14 to 0.26 mm, dermal thickness from 0.90 to 1.51 mm and the elasticity index from 47% to 71%. In the Imedeen group, epidermal thickness increased from 0.13 to 0.18 mm, dermal thickness from 0.80 to 0.97 mm and the elasticity index from 48% to 56%. After 90 days, the differences between the two groups for all three parameters were statistically significant (P less than 0.001). The mean erythemal index decreased from 0.24 to 0.20 in the Vidida group, but increased from 0.23 to 0.25 in the Imedeen group. In the Vivida group, five patients developed transient, mild pimples during the first weeks of treatment, but no other adverse effects occurred.
越来越多的证据表明，源自海鱼的软骨多糖对日光性弹力纤维变性具有修复作用。在一项双盲试验中，比较了两种商业制剂Vivida和伊美婷（Imedeen）对40至60岁女性晒伤皮肤的疗效和安全性。一组15名女性每天口服500毫克Vivida，另一组15名女性每天口服380毫克伊美婷，持续90天。主观评估显示，两个治疗组的皮肤状况均有统计学上的显著改善，但在所有参数方面，Vivida比伊美婷显著更有效（P小于0.01）。在Vivida组中，平均表皮厚度从0.14毫米增加到0.26毫米，真皮厚度从0.90毫米增加到1.51毫米，弹性指数从47%增加到71%。在伊美婷组中，表皮厚度从0.13毫米增加到0.18毫米，真皮厚度从0.80毫米增加到0.97毫米，弹性指数从48%增加到56%。90天后，两组在所有三个参数上的差异均具有统计学意义（P小于0.001）。Vivida组的平均红斑指数从0.24降至0.20，而伊美婷组则从0.23升至0.25。在Vivida组中，有5名患者在治疗的第一周出现了短暂的轻度丘疹，但未发生其他不良反应。
