Lassus A, Jeskanen L, Happonen H P, Santalahti J
Department of Dermatology, University Central Hospital, Helsinki, Finland.
J Int Med Res. 1991 Mar-Apr;19(2):147-52. doi: 10.1177/030006059101900208.
Imedeen, a new compound for oral administration consisting of special protein fractions and some glucosaminoglycans extracted from marine fish, has been shown in previous pilot studies to have a repairing effect on sun-damaged skin. In an open study, 10 females with sun-damaged skin, aged 39-61 years, were treated with 0.5 g/day Imedeen for 90 days. At baseline and after 30, 60 and 90 days, the following parameters were clinically evaluated: wrinkles; mottles; dryness of skin; and brittleness of hair and nails. After 90 days' treatment all signs of sun-damage had improved and brittleness of hair and nails was normalized in all cases. These clinical observations were confirmed by changes in skin thickness and elasticity. In a second double-blind study, 30 females in the same age range and with similar signs of sun-damage were treated with 0.5 g/day Imedeen or placebo for 90 days. The results in the Imedeen-treated group corresponded to those in the first study whereas no response to treatment was observed in the placebo treatment group.
伊美婷是一种新型口服化合物，由从海鱼中提取的特殊蛋白质组分和一些氨基葡聚糖组成。先前的初步研究表明，它对晒伤皮肤具有修复作用。在一项开放性研究中，10名年龄在39至61岁之间、皮肤有晒伤的女性，每天服用0.5克伊美婷，持续90天。在基线以及30天、60天和90天后，对以下参数进行了临床评估：皱纹；斑点；皮肤干燥；头发和指甲的脆性。经过90天的治疗，所有晒伤迹象均有所改善，所有受试者的头发和指甲脆性均恢复正常。这些临床观察结果通过皮肤厚度和弹性的变化得到了证实。在第二项双盲研究中，30名年龄范围相同、有类似晒伤迹象的女性，每天服用0.5克伊美婷或安慰剂，持续90天。伊美婷治疗组的结果与第一项研究一致，而安慰剂治疗组未观察到治疗反应。
