Bendtsen T F, Nyengaard J R
Stereological Research Laboratory, Aarhus University, Denmark.
Diabetologia. 1992 Sep;35(9):844-50. doi: 10.1007/BF00399930.
The number of glomeruli per kidney in Type 1 (insulin-dependent) and Type 2 (non-insulin-dependent) diabetic patients was estimated by an unbiased stereological method: the fractionator. No significant differences were observed between Type 1 and Type 2 diabetic patients without severe diabetic glomerulopathy and non-diabetic patients. Diabetic patients with proteinuria who were in the early stages of diabetic nephropathy also had a normal number of glomeruli. On the other hand, a subgroup classified as Type 1 diabetic patients with severe diabetic glomerulopathy had significantly less glomeruli compared with Type 1 diabetic patients with mild or no glomerulopathy. A probable explanation is that Type 1 diabetic patients lose glomeruli in relation to the progression of diabetic glomerulopathy. A more theoretical alternative is, however, that development of diabetic glomerulopathy is facilitated by a low number of glomeruli.
采用无偏倚的体视学方法（分样法）估算1型（胰岛素依赖型）和2型（非胰岛素依赖型）糖尿病患者每个肾脏的肾小球数量。在无严重糖尿病性肾小球病的1型和2型糖尿病患者与非糖尿病患者之间未观察到显著差异。处于糖尿病肾病早期且有蛋白尿的糖尿病患者肾小球数量也正常。另一方面，分类为患有严重糖尿病性肾小球病的1型糖尿病患者亚组与患有轻度或无肾小球病的1型糖尿病患者相比，肾小球数量显著减少。一种可能的解释是，1型糖尿病患者的肾小球数量会随着糖尿病性肾小球病的进展而减少。然而，另一种更具理论性的观点是，肾小球数量少会促进糖尿病性肾小球病的发展。
