Hattori T, Yamada S, Furuta K, Nagamatsu T, Ito M, Suzuki Y
Department of Pharmacology, Faculty of Pharmacy, Meijo University, Nagoya, Japan.
Nihon Yakurigaku Zasshi. 1992 Jun;99(6):391-9. doi: 10.1254/fpj.99.391.
Effects of pherodendrin (OB-5) on anti-GBM nephritis were investigated. OB-5 (50 mg/kg/day, i.p.) prevented the urinary protein excretion in original and crescentic-type anti-GBM nephritis in rats. In addition, OB-5 also inhibited the elevation of serum creatinine, urea nitrogen and cholesterol contents in both models of nephritis. Histopathological observations indicated that OB-5 prevented the hypercellularity, crescent formation, adhesion and fibrinoid necrosis in the glomeruli of nephritic rats. OB-5 and cyclosporine A, a positive control drug, prevented the increase in the number of OX-1, CD8 and ED-1 positive cells in the glomeruli. These results indicated that OB-5 may be effective in human glomerulonephritis, and anti-nephritic mechanisms of OB-5 may be due to its inhibition of the activation of macrophages or cytotoxic T cells.
研究了pherodendrin（OB-5）对抗肾小球基底膜（GBM）肾炎的影响。OB-5（50毫克/千克/天，腹腔注射）可预防大鼠原发性和新月体型抗GBM肾炎中的尿蛋白排泄。此外，在两种肾炎模型中，OB-5还抑制了血清肌酐、尿素氮和胆固醇含量的升高。组织病理学观察表明，OB-5可预防肾炎大鼠肾小球中的细胞增多、新月体形成、粘连和纤维蛋白样坏死。OB-5和阳性对照药物环孢素A可预防肾小球中OX-1、CD8和ED-1阳性细胞数量的增加。这些结果表明，OB-5可能对人类肾小球肾炎有效，其抗肾炎机制可能是由于其抑制巨噬细胞或细胞毒性T细胞的激活。
