Hattori T, Hayashi K, Nagao T, Furuta K, Ito M, Suzuki Y
Department of Pharmacology, Faculty of Pharmacy, Meijo University, Nagoya, Japan.
Jpn J Pharmacol. 1992 May;59(1):89-96. doi: 10.1254/jjp.59.89.
The antinephritic effect of pachyman on original-type anti-GBM nephritis in rats was investigated. Pachyman was given to original-type anti-GBM nephritic rats for 10 days from the day of anti-GBM serum injection. Pachyman prevented urinary protein excretion and the elevation of serum cholesterol content. Histopathological observations of the glomeruli indicated that although the number of nuclei and adhesion to capillary walls of Bowman's capsule in nephritic control rats were significantly increased, pachyman reduced the degree of histopathological changes such as hypercellularity and adhesion as compared to the control group. Although the serum complement CH50 ratio in control group was significantly lower than that in the normal group, the decrease in serum complement CH50 was inhibited by pachyman, and rat C3 deposition in the glomeruli in the pachyman-treated group was significantly reduced. These results suggest that pachyman was effective against original-type anti-GBM nephritis in rats and that the antinephritic mechanisms of pachyman may be partly due to the inhibitory action of this agent on C3 deposition in the glomeruli.
研究了茯苓对大鼠原型抗肾小球基底膜（GBM）肾炎的抗肾炎作用。从注射抗GBM血清之日起，给原型抗GBM肾炎大鼠服用茯苓10天。茯苓可防止尿蛋白排泄及血清胆固醇含量升高。肾小球的组织病理学观察表明，虽然肾炎对照组大鼠的细胞核数量及与鲍曼囊毛细血管壁的粘连显著增加，但与对照组相比，茯苓减轻了细胞增多和粘连等组织病理学变化的程度。虽然对照组的血清补体CH50比值显著低于正常组，但茯苓可抑制血清补体CH50的降低，且茯苓治疗组大鼠肾小球中的C3沉积显著减少。这些结果表明，茯苓对大鼠原型抗GBM肾炎有效，其抗肾炎机制可能部分归因于该药物对肾小球中C3沉积的抑制作用。
