Beuscher H U, Rausch U P, Röllinghoff M
Institut für Klinische Mikrobiologie und Infektionshygiene, Universität Erlangen-Nürnberg, Federal Republic of Germany.
Immun Infekt. 1992 Aug;20(4):128-33.
Interleukin(IL-)-1 is the prototype of a proinflammatory cytokine, produced in response to infection and other forms of trauma. At low concentrations IL-1 brings about increases in a number of defense mechanisms, particularly immunologic and inflammatory responses. However, over- or continued production of IL-1, as seen for example during septic infection, significantly contributes to pathological reactions such as hemodynamic shock. Thus, it is not surprising that IL-1 activities are tightly regulated, most notably at the levels of transcription and secretion. Additional regulation is provided by the action of a protein, that blocks the binding of IL-1 to its receptors. This protein, termed IL-1-receptor antagonist (IL-1ra) has been cloned recently, and may provide the possibility of specific therapeutic measures.
白细胞介素（IL）-1是促炎细胞因子的原型，在对感染和其他形式的创伤作出反应时产生。低浓度的IL-1会引发多种防御机制的增强，尤其是免疫和炎症反应。然而，如在脓毒症感染期间所见，IL-1的过度产生或持续产生会显著导致诸如血流动力学休克等病理反应。因此，IL-1的活性受到严格调控并不奇怪，最显著的是在转录和分泌水平。一种蛋白质的作用提供了额外的调控，这种蛋白质可阻断IL-1与其受体的结合。这种蛋白质被称为IL-1受体拮抗剂（IL-1ra），最近已被克隆，可能为特定治疗措施提供可能性。
