Scalise F, Gerli R, Castellucci G, Spinozzi F, Fabietti G M, Crupi S, Sensi L, Britta R, Vaccaro R, Bertotto A
Department of Paediatrics, Perugia University Medical School, Italy.
Immunology. 1992 Aug;76(4):668-70.
Although the relative and absolute numbers of CD3+ cells (T lymphocytes) were similar in eight children with acquired Toxoplasma gondii infection and 10 uninfected age- and sex-matched healthy controls, the proportion of cells bearing the gamma delta T-cell receptor was significantly higher in the subjects with acute toxoplasmosis. The great majority of gamma delta T cells from the infected patients expressed covalently bound gamma delta chains on their surface, i.e. were BB3+ lymphocytes. Since the gamma delta T-cell subsets exert both restricted and unrestricted major histocompatibility complex cytotoxicity, further research is needed to elucidate the role of gamma delta T cells in the control of this coccidian protozoan infection.
虽然8名获得性弓形虫感染儿童与10名年龄和性别匹配的未感染健康对照者的CD3+细胞（T淋巴细胞）相对数量和绝对数量相似，但急性弓形虫病患者中携带γδ T细胞受体的细胞比例显著更高。感染患者的绝大多数γδ T细胞在其表面表达共价结合的γδ链，即BB3+淋巴细胞。由于γδ T细胞亚群发挥有限和非限制性主要组织相容性复合体细胞毒性，因此需要进一步研究以阐明γδ T细胞在控制这种球虫原虫感染中的作用。
