CD45RO（UCHL1）在循环TCR-γ/δ⁺淋巴细胞两个亚群中的差异表达及其功能相关性
Differential expression of CD45RO (UCHL1) and its functional relevance in two subpopulations of circulating TCR-gamma/delta+ lymphocytes.
作者信息
Miyawaki T, Kasahara Y, Taga K, Yachie A, Taniguchi N
机构信息
Department of Pediatrics, School of Medicine, Kanazawa University, Kanazawa, Ishikawa, Japan.
出版信息
J Exp Med. 1990 May 1;171(5):1833-8. doi: 10.1084/jem.171.5.1833.
We examined the developmental profile of TCR-gamma/delta+ cells with respect to CD45RO expression. Although total TCR-gamma/delta+ cells were negligible in the neonatal blood and increased with advancing age, most blood TCR-gamma/delta+ cells markedly expressed CD45RO without a distinction of age, probably reflecting a different CD45RO expression of two subsets defined by BB3 and delta TCS1 mAbs. The vast majority of BB3+ cells expressed CD45RO, whereas expression of CD45RO was virtually absent in the delta TCS1+ population. Functional studies revealed that, while both TCR-gamma/delta+ cell subsets showed CD3-mediated activation, only BB3+ (or Ti gamma A+) cells, but not delta TCS1+ cells, appeared to proliferate in response to PPD in PPD-reactive individuals. The results suggested that the CD45RO+ (BB3+ or Ti gamma A+) subset among blood TCR-gamma/delta+ cells may be mainly involved in the memory or primed component of the immune system responding to some foreign antigens.
我们研究了TCR-γ/δ⁺细胞关于CD45RO表达的发育概况。虽然新生儿血液中的总TCR-γ/δ⁺细胞数量可忽略不计且随年龄增长而增加，但大多数血液中的TCR-γ/δ⁺细胞显著表达CD45RO，且无年龄差异，这可能反映了由BB3和δTCS1单克隆抗体定义的两个亚群不同的CD45RO表达情况。绝大多数BB3⁺细胞表达CD45RO，而δTCS1⁺群体中几乎不存在CD45RO的表达。功能研究表明，虽然两个TCR-γ/δ⁺细胞亚群均显示出CD3介导的激活，但在对PPD有反应的个体中，只有BB3⁺（或TiγA⁺）细胞，而非δTCS1⁺细胞，似乎会对PPD产生增殖反应。结果表明，血液中TCR-γ/δ⁺细胞中的CD45RO⁺（BB3⁺或TiγA⁺）亚群可能主要参与免疫系统对某些外来抗原反应的记忆或致敏成分。
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