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新型细胞因子肝细胞生长因子对中性粒细胞的启动作用

Neutrophil priming by hepatocyte growth factor, a novel cytokine.

作者信息

Jiang W, Puntis M C, Nakamura T, Hallett M B

机构信息

University Department of Surgery, University of Wales College of Medicine, Cardiff, U.K.

出版信息

Immunology. 1992 Sep;77(1):147-9.

PMID:1398762
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1421591/
Abstract

We demonstrate here that the recently defined cytokine hepatocyte growth factor (HGF) 'primes' human neutrophils. Recombinant human HGF over the concentration range 0.1-20 ng/ml increased the neutrophil response to f-met-leu-phe by up to 200%, and required only a short preincubation, 10 min producing the maximum effect. Priming was independent of changes in cytosolic-free calcium homeostasis. We conclude that HGF may be a physiologically important cytokine with 'priming' activity for neutrophils.

摘要

我们在此证明，最近定义的细胞因子肝细胞生长因子（HGF）可“启动”人类中性粒细胞。浓度范围在0.1 - 20 ng/ml的重组人HGF可使中性粒细胞对f-甲硫-亮-苯丙氨酸的反应增强达200%，且仅需短暂预孵育，10分钟时产生最大效应。启动作用与胞质游离钙稳态的变化无关。我们得出结论，HGF可能是一种对中性粒细胞具有“启动”活性的重要生理细胞因子。

相似文献

1
Neutrophil priming by hepatocyte growth factor, a novel cytokine.新型细胞因子肝细胞生长因子对中性粒细胞的启动作用
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2
Interleukin-8 primes human neutrophils for enhanced superoxide anion production.白细胞介素-8使人类中性粒细胞做好准备，以增强超氧阴离子的产生。
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Leukocyte inhibitory factor (LIF) potentiates neutrophil responses to formyl-methionyl-leucyl-phenylalanine.白细胞抑制因子（LIF）增强中性粒细胞对甲酰甲硫氨酰亮氨酰苯丙氨酸的反应。
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Oxidized N-formylmethionyl-leucyl-phenylalanine: effect on the activation of human monocyte and neutrophil chemotaxis and superoxide production.氧化型N-甲酰甲硫氨酰-亮氨酰-苯丙氨酸：对人单核细胞和中性粒细胞趋化性激活及超氧化物产生的影响。
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本文引用的文献

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Stimulation of Ca2+-dependent chemiluminescence in rat polymorphonuclear leucocytes by polystyrene beads and the non-lytic action of complement.聚苯乙烯珠对大鼠多形核白细胞中钙依赖性化学发光的刺激及补体的非溶细胞作用。
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The use of fura-2 to determine the relationship between cytoplasmic free Ca2+ and oxidase activation in rat neutrophils.使用fura-2测定大鼠中性粒细胞胞质游离Ca2+与氧化酶激活之间的关系。
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Purification and partial characterization of hepatocyte growth factor from plasma of a patient with fulminant hepatic failure.暴发性肝衰竭患者血浆中肝细胞生长因子的纯化及部分特性分析
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6
Marked increase of HGF mRNA in non-parenchymal liver cells of rats treated with hepatotoxins.用肝毒素处理的大鼠非实质肝细胞中HGF mRNA显著增加。
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Neutrophil-activating peptide-1/interleukin 8, a novel cytokine that activates neutrophils.中性粒细胞激活肽-1/白细胞介素8，一种激活中性粒细胞的新型细胞因子。
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Tumor necrosis factor alpha potentiates neutrophil antimicrobial activity: increased fungicidal activity against Torulopsis glabrata and Candida albicans and associated increases in oxygen radical production and lysosomal enzyme release.肿瘤坏死因子α增强中性粒细胞的抗菌活性：增强对光滑球拟酵母菌和白色念珠菌的杀真菌活性，并伴随氧自由基产生和溶酶体酶释放增加。
Infect Immun. 1989 Jul;57(7):2115-22. doi: 10.1128/iai.57.7.2115-2122.1989.
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Effect of tumor necrosis factor and granulocyte/macrophage colony-stimulating factor on neutrophil degranulation.肿瘤坏死因子和粒细胞/巨噬细胞集落刺激因子对中性粒细胞脱颗粒的影响。
J Immunol. 1989 May 1;142(9):3199-205.
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Effect of granulocyte-macrophage colony-stimulating factor on superoxide production in cytoplasts and intact human neutrophils: role of protein kinase and G-proteins.粒细胞-巨噬细胞集落刺激因子对细胞质体和完整人中性粒细胞中超氧化物产生的影响：蛋白激酶和G蛋白的作用。
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