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Immunology. 1992 Jan;75(1):157-63.
2
Interleukin-8 primes human neutrophils for enhanced superoxide anion production.白细胞介素-8使人类中性粒细胞做好准备，以增强超氧阴离子的产生。
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Tumor necrosis factor-alpha priming of phospholipase A2 activation in human neutrophils. An alternative mechanism of priming.肿瘤坏死因子-α引发人中性粒细胞中磷脂酶A2的激活。一种引发的替代机制。
J Immunol. 1991 Feb 15;146(4):1277-85.
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Activation of NADPH oxidase in human neutrophils. Synergism between fMLP and the neutrophil products PAF and LTB4.人中性粒细胞中NADPH氧化酶的激活。fMLP与中性粒细胞产物PAF和LTB4之间的协同作用。
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Blood. 1998 May 1;91(9):3423-9.

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Rapid microassays for the measurement of superoxide and hydrogen peroxide production by macrophages in culture using an automatic enzyme immunoassay reader.使用自动酶免疫测定仪对培养的巨噬细胞产生超氧化物和过氧化氢进行测量的快速微量测定法。
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Leukotriene B, a potent chemokinetic and aggregating substance released from polymorphonuclear leukocytes.白三烯B，一种从多形核白细胞释放的强效化学趋化和聚集物质。
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Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g.从人血中分离单核细胞和粒细胞。通过一次离心分离单核细胞，通过离心和1g沉降相结合的方法分离粒细胞。
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Molecular cloning of a human monocyte-derived neutrophil chemotactic factor (MDNCF) and the induction of MDNCF mRNA by interleukin 1 and tumor necrosis factor.人单核细胞衍生的中性粒细胞趋化因子（MDNCF）的分子克隆以及白细胞介素1和肿瘤坏死因子对MDNCF mRNA的诱导作用
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重组人单核细胞白细胞介素-8引发人中性粒细胞中NADPH氧化酶和磷脂酶A2的激活。

Recombinant human monocyte IL-8 primes NADPH-oxidase and phospholipase A2 activation in human neutrophils.

作者信息

Daniels R H, Finnen M J, Hill M E, Lackie J M

机构信息

Yamanouchi Research Institute (U.K.), Littlemore Hospital, Oxford.

出版信息

Immunology. 1992 Jan;75(1):157-63.

PMID:1537592
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1384818/
Abstract

We demonstrate for the first time that recombinant human monocyte interleukin-8 (rhMIL-8) primes human neutrophil responses to fMLP. Human neutrophils preincubated for 10 min with 10(-8) M rhMIL-8 and then stimulated with micromolar fMLP show enhanced release of superoxide anions, platelet-activating factor (PAF) and arachidonic acid compared with cells which are not initially exposed to rhMIL-8. We also demonstrate that this enhancement of the neutrophil response is dependent on the dose of rhMIL-8 with the greatest enhancement corresponding with IL-8 levels which cause maximum shape change of neutrophils. Priming of neutrophils occurred after only 30 seconds preincubation with rhMIL-8 indicating that the mechanism of IL-8 priming is extremely rapid as was stimulation of neutrophil shape change by rhMIL-8. Priming of neutrophils with rhMIL-8 did not increase sensitivity to fMLP but enhanced responsiveness to activating concentrations. rhMIL-8 alone at levels used for priming caused no release of superoxide anions, arachidonic acid or PAF. These results suggest that IL-8 primes neutrophil phospholipase A2 and NADPH-oxidase activation in response to fMLP.

摘要

我们首次证明重组人单核细胞白细胞介素-8（rhMIL-8）可使人类中性粒细胞对fMLP的反应致敏。与未预先接触rhMIL-8的细胞相比，用10(-8) M rhMIL-8预孵育10分钟，然后用微摩尔浓度的fMLP刺激的人类中性粒细胞，超氧阴离子、血小板活化因子（PAF）和花生四烯酸的释放增强。我们还证明，中性粒细胞反应的这种增强取决于rhMIL-8的剂量，最大增强与导致中性粒细胞最大形态变化的IL-8水平相对应。用rhMIL-8预孵育仅30秒后中性粒细胞就发生了致敏，这表明IL-8致敏机制极其迅速，rhMIL-8刺激中性粒细胞形态变化也是如此。用rhMIL-8使中性粒细胞致敏不会增加对fMLP的敏感性，但会增强对激活浓度的反应性。用于致敏的rhMIL-8单独存在时，不会导致超氧阴离子、花生四烯酸或PAF的释放。这些结果表明，IL-8可使中性粒细胞磷脂酶A2和NADPH氧化酶在对fMLP的反应中活化。