SELLER M J, SPECTOR R G
Br J Pharmacol Chemother. 1962 Oct;19(2):271-3. doi: 10.1111/j.1476-5381.1962.tb01188.x.
Leptazol B.P. (0.2 ml./kg) produced convulsions in 65% of normal adult rats with no fatalities. The same dose of leptazol in animals which had previously been given 0.125 mg/kg aldosterone resulted in fits in 70.2% with 7.7% deaths. Cortisol pretreatment (25 mg/kg) resulted in fits in 82.9%, and 12.2% of the animals died in convulsions. The incidence of convulsions in the animals treated with aldosterone and leptazol was not significantly increased above the animals treated with leptazol. The cortisol-leptazol group did exhibit a significantly raised incidence of fits.
英国药典中的戊四氮（0.2毫升/千克）可使65%的正常成年大鼠发生惊厥，无一死亡。在先前已给予0.125毫克/千克醛固酮的动物中，相同剂量的戊四氮导致70.2%的动物发生惊厥，7.7%死亡。预先给予皮质醇（25毫克/千克）导致82.9%的动物发生惊厥，12.2%的动物死于惊厥。用醛固酮和戊四氮治疗的动物惊厥发生率相比仅用戊四氮治疗的动物无显著增加。皮质醇 - 戊四氮组惊厥发生率确实显著升高。
