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The effects of intracerebroventricularly administered noradnamine and other sympathomimetic amines upon leptazol convulsions in mice.脑室内注射去甲肾上腺素及其他拟交感胺对小鼠戊四氮惊厥的影响。
Br J Pharmacol. 1968 Sep;34(1):27-31. doi: 10.1111/j.1476-5381.1968.tb07946.x.
2
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8
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Modifying the subunit composition of TASK channels alters the modulation of a leak conductance in cerebellar granule neurons.改变TASK通道的亚基组成会改变小脑颗粒神经元中漏导的调节。
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The involvement of noradrenaline, 5-hydroxytryptamine and acetylcholine in imipramine-induced seizures in mice.去甲肾上腺素、5-羟色胺和乙酰胆碱在丙咪嗪诱发小鼠癫痫发作中的作用。
Experientia. 1993 Oct 15;49(10):859-64. doi: 10.1007/BF01952598.
3
Studies on interactions involving antidepressive and other drugs with tetrabenazine and noradnamine on locomotor activity in mice, including details of the experimental design and statistical analysis.关于抗抑郁药和其他药物与丁苯那嗪及去甲肾上腺素对小鼠运动活性相互作用的研究，包括实验设计和统计分析的详细内容。
Psychopharmacologia. 1970;18(3):288-99. doi: 10.1007/BF00412674.
4
Convulsions elicited by handling: a sensitive method of measuring CNS excitation in mice treated with reserpine or convulsant drugs.
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本文引用的文献

1
Evaluation of antiepileptic drugs.抗癫痫药物的评估
Arch Neurol Psychiatry. 1950 Jan;63(1):56-60. doi: 10.1001/archneurpsyc.1950.02310190062004.
2
Anticonvulsant properties of monoamine oxidase inhibitors.
Ann N Y Acad Sci. 1959 Sep 17;80:643-51. doi: 10.1111/j.1749-6632.1959.tb49242.x.
3
Potentiating action of chlorpromazine and reserpine.氯丙嗪和利血平的增效作用。
Nature. 1955 Jun 25;175(4469):1133-4. doi: 10.1038/1751133a0.
4
TREATMENT OF DEPRESSION.抑郁症的治疗
Lancet. 1965 Jun 5;1(7397):1219-20. doi: 10.1016/s0140-6736(65)92750-9.
5
Brain amines and electroshock threshold.脑胺与电休克阈值
Arch Int Pharmacodyn Ther. 1962 Dec 1;140:358-67.
6
Release of serotonin and catecholamines by drugs.药物引起的血清素和儿茶酚胺释放。
Pharmacol Rev. 1962 Dec;14:531-50.
7
Origin and blockade of the synaptic responses of curarized sympathetic ganglia.箭毒处理的交感神经节突触反应的起源与阻断
J Physiol. 1961 Aug;157(3):484-503. doi: 10.1113/jphysiol.1961.sp006738.
8
The anti-reserpine effects of certain centrally-acting agents.某些中枢作用药物的抗利血平作用。
J Pharmacol Exp Ther. 1961 Feb;131:179-84.
9
The effects of reserpine and other agents upon leptazol convulsions in mice.利血平和其他药物对小鼠戊四氮惊厥的影响。
Br J Pharmacol Chemother. 1959 Mar;14(1):108-11. doi: 10.1111/j.1476-5381.1959.tb00935.x.
10
[Influence of changes of serotonin content of the central nervous system on the seizure threshold of cardiazol].[中枢神经系统血清素含量变化对戊四氮惊厥阈值的影响]
Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1958;233(6):559-66.

脑室内注射去甲肾上腺素及其他拟交感胺对小鼠戊四氮惊厥的影响。

The effects of intracerebroventricularly administered noradnamine and other sympathomimetic amines upon leptazol convulsions in mice.

作者信息

Jones B J, Roberts D J

出版信息

Br J Pharmacol. 1968 Sep;34(1):27-31. doi: 10.1111/j.1476-5381.1968.tb07946.x.

DOI:10.1111/j.1476-5381.1968.tb07946.x
PMID:4877601
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1703447/
Abstract
  1. The influence of some intracerebroventricularly administered sympathomimetic amines on leptazol-induced convulsions has been investigated.2. Noradnamine and high doses of dopamine proved to be anticonvulsant and also antagonized the facilitative effects of reserpine.3. Noradrenaline and octopamine also antagonized reserpine-induced facilitation but were without effect on leptazol alone; by contrast tyramine and small doses of dopamine lowered the threshold for leptazol convulsions.4. A possible interpretation of these results is presented.
摘要

  1. 研究了一些经脑室内注射的拟交感神经胺对戊四氮诱发惊厥的影响。

  2. 去甲肾上腺素和高剂量多巴胺被证明具有抗惊厥作用，并且还拮抗利血平的促惊厥作用。

  3. 去甲肾上腺素和章鱼胺也拮抗利血平诱发的惊厥易化作用，但对单独使用戊四氮无作用；相反，酪胺和小剂量多巴胺降低了戊四氮惊厥的阈值。

  4. 对这些结果给出了一种可能的解释。