生物胺合成的阻断：其对大鼠戊四氮和右旋苯丙胺反应的影响。
Blockade of biogenic amine synthesis: its effect on the responses to leptazol and dexamphetamine in rats.
作者信息
Spencer P S, Turner T A
出版信息
Br J Pharmacol. 1969 Sep;37(1):94-103. doi: 10.1111/j.1476-5381.1969.tb09526.x.
Abstract
- The convulsive effects of leptazol in the rat are potentiated by prior treatment with dexamphetamine.2. An intact dopamine synthesis is necessary for the potentiation of the convulsive action of leptazol.3. An intact noradrenaline synthesis is not necessary for this action of amphetamine, as long as the dopamine synthesis is intact.4. An intact 5-hydroxytryptamine synthesis is not necessary for the potentiation to be shown.5. Blockade of either noradrenaline, dopamine or 5-hydroxytryptamine synthesis has no direct effect on leptazol convulsions.6. It is possible that it is an intact 3-4 dihydroxyphenylalanine (dopa) synthesis rather than an intact dopamine synthesis that is involved.
摘要
用右旋苯丙胺预先处理可增强戊四氮对大鼠的惊厥作用。
完整的多巴胺合成对于增强戊四氮的惊厥作用是必要的。
只要多巴胺合成完整，去甲肾上腺素合成完整对于苯丙胺的这种作用并非必要。
5-羟色胺合成完整对于显示这种增强作用并非必要。
去甲肾上腺素、多巴胺或5-羟色胺合成的阻断对戊四氮惊厥无直接影响。
有可能涉及的是完整的3,4-二羟基苯丙氨酸（多巴）合成而非完整的多巴胺合成。
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