• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Rhodopseudomonas sphaeroides lipid A derivatives block in vitro induction of tumor necrosis factor and endotoxin tolerance by smooth lipopolysaccharide and monophosphoryl lipid A.球形红假单胞菌脂多糖A衍生物可阻断光滑型脂多糖和单磷酰脂A在体外诱导肿瘤坏死因子和内毒素耐受。
Infect Immun. 1992 Oct;60(10):4285-90. doi: 10.1128/iai.60.10.4285-4290.1992.
2
Diphosphoryl lipid A obtained from the nontoxic lipopolysaccharide of Rhodopseudomonas sphaeroides is an endotoxin antagonist in mice.从球形红假单胞菌无毒脂多糖中获得的二磷酸脂质A是小鼠体内的一种内毒素拮抗剂。
Infect Immun. 1991 Jan;59(1):441-4. doi: 10.1128/iai.59.1.441-444.1991.
3
Diphosphoryl lipid A from Rhodopseudomonas sphaeroides ATCC 17023 blocks induction of cachectin in macrophages by lipopolysaccharide.球形红假单胞菌ATCC 17023的双磷酸脂A可阻断脂多糖诱导巨噬细胞中恶病质素的产生。
Infect Immun. 1989 Apr;57(4):1336-8. doi: 10.1128/iai.57.4.1336-1338.1989.
4
In vivo inhibition of lipopolysaccharide-induced lethality and tumor necrosis factor synthesis by Rhodobacter sphaeroides diphosphoryl lipid A is dependent on corticosterone induction.球形红细菌双磷酸脂质A对脂多糖诱导的致死率和肿瘤坏死因子合成的体内抑制作用依赖于皮质酮诱导。
Infect Immun. 1992 Jul;60(7):2581-7. doi: 10.1128/iai.60.7.2581-2587.1992.
5
CD14 is not involved in Rhodobacter sphaeroides diphosphoryl lipid A inhibition of tumor necrosis factor alpha and nitric oxide induction by taxol in murine macrophages.CD14不参与球形红杆菌二磷酸脂质A对紫杉醇诱导小鼠巨噬细胞产生肿瘤坏死因子α和一氧化氮的抑制作用。
Infect Immun. 1995 Feb;63(2):486-97. doi: 10.1128/iai.63.2.486-497.1995.
6
Diphosphoryl lipid A from Rhodopseudomonas sphaeroides induces tolerance to endotoxic shock in the rat.球形红假单胞菌的双磷酸脂A可诱导大鼠对内毒素休克产生耐受性。
Crit Care Med. 1993 May;21(5):753-8. doi: 10.1097/00003246-199305000-00020.
7
Structure-activity relationships of lipopolysaccharide (LPS) in tumor necrosis factor-alpha (TNF-alpha) production and induction of macrophage cell death in the presence of cycloheximide (CHX) in a murine macrophage-like cell line, J774.1.在小鼠巨噬细胞样细胞系J774.1中，脂多糖（LPS）在肿瘤坏死因子-α（TNF-α）产生以及在存在放线菌酮（CHX）的情况下诱导巨噬细胞死亡方面的构效关系。
Biol Pharm Bull. 1998 Oct;21(10):1102-5. doi: 10.1248/bpb.21.1102.
8
Grain dust-induced lung inflammation is reduced by Rhodobacter sphaeroides diphosphoryl lipid A.球形红细菌双磷酸化脂多糖可减轻谷物粉尘引起的肺部炎症。
Am J Physiol. 1998 Jan;274(1):L26-31. doi: 10.1152/ajplung.1998.274.1.L26.
9
Diphosphoryl lipid A derived from lipopolysaccharide (LPS) of Rhodopseudomonas sphaeroides inhibits activation of 70Z/3 cells by LPS.源自球形红假单胞菌脂多糖（LPS）的二磷酸脂A可抑制LPS对70Z/3细胞的激活作用。
Infect Immun. 1991 Jan;59(1):131-6. doi: 10.1128/iai.59.1.131-136.1991.
10
Modulation of lipopolysaccharide-induced macrophage gene expression by Rhodobacter sphaeroides lipid A and SDZ 880.431.球形红杆菌脂多糖A和SDZ 880.431对脂多糖诱导的巨噬细胞基因表达的调节作用
Infect Immun. 1993 Aug;61(8):3518-26. doi: 10.1128/iai.61.8.3518-3526.1993.

引用本文的文献

1
A mouse model of human TLR4 D299G/T399I SNPs reveals mechanisms of altered LPS and pathogen responses.人类 TLR4 D299G/T399I 单核苷酸多态性的小鼠模型揭示了 LPS 和病原体反应改变的机制。
J Exp Med. 2021 Feb 1;218(2). doi: 10.1084/jem.20200675.
2
Lipid A-mediated tolerance and cancer therapy.脂 A 介导的耐受和癌症治疗。
Adv Exp Med Biol. 2010;667:81-99. doi: 10.1007/978-1-4419-1603-7_8.
3
A combination of proteasome inhibitors and antibiotics prevents lethality in a septic shock model.蛋白酶体抑制剂和抗生素的联合使用可预防脓毒症休克模型中的致死率。
Innate Immun. 2008 Oct;14(5):319-29. doi: 10.1177/1753425908096855.
4
Differential activation of human TLR4 by Escherichia coli and Shigella flexneri 2a lipopolysaccharide: combined effects of lipid A acylation state and TLR4 polymorphisms on signaling.大肠杆菌和福氏志贺菌2a脂多糖对人TLR4的差异激活：脂多糖A酰化状态和TLR4多态性对信号传导的联合影响
J Immunol. 2008 Jan 15;180(2):1139-47. doi: 10.4049/jimmunol.180.2.1139.
5
Regulation of cellular caveolin-1 protein expression in murine macrophages by microbial products.微生物产物对小鼠巨噬细胞中细胞小窝蛋白-1蛋白表达的调控
Infect Immun. 2005 Dec;73(12):8136-43. doi: 10.1128/IAI.73.12.8136-8143.2005.
6
Mechanisms involved in the pathogenesis of sepsis are not necessarily reflected by in vitro cell activation studies.脓毒症发病机制中所涉及的机制不一定能通过体外细胞激活研究反映出来。
Infect Immun. 1998 Nov;66(11):5372-8. doi: 10.1128/IAI.66.11.5372-5378.1998.
7
Lipopolysaccharide and monophosphoryl lipid A differentially regulate interleukin-12, gamma interferon, and interleukin-10 mRNA production in murine macrophages.脂多糖和单磷酰脂质A对小鼠巨噬细胞中白细胞介素-12、γ干扰素和白细胞介素-10 mRNA的产生有不同的调节作用。
Infect Immun. 1997 Aug;65(8):3239-47. doi: 10.1128/iai.65.8.3239-3247.1997.
8
Lipoteichoic acid preparations of gram-positive bacteria induce interleukin-12 through a CD14-dependent pathway.革兰氏阳性菌的脂磷壁酸制剂通过依赖CD14的途径诱导白细胞介素-12。
Infect Immun. 1996 Jun;64(6):1906-12. doi: 10.1128/iai.64.6.1906-1912.1996.
9
Dissociation of lipopolysaccharide (LPS)-inducible gene expression in murine macrophages pretreated with smooth LPS versus monophosphoryl lipid A.用光滑型脂多糖与单磷酰脂质A预处理的小鼠巨噬细胞中脂多糖（LPS）诱导基因表达的解离
Infect Immun. 1993 Jun;61(6):2325-33. doi: 10.1128/iai.61.6.2325-2333.1993.
10
Modulation of lipopolysaccharide-induced macrophage gene expression by Rhodobacter sphaeroides lipid A and SDZ 880.431.球形红杆菌脂多糖A和SDZ 880.431对脂多糖诱导的巨噬细胞基因表达的调节作用
Infect Immun. 1993 Aug;61(8):3518-26. doi: 10.1128/iai.61.8.3518-3526.1993.

本文引用的文献

1
EFFECTS PRODUCED BY THE INTRAVENOUS INJECTION IN MAN OF A TOXIC ANTIGENIC MATERIAL DERIVED FROM EBERTHELLA TYPHOSA: CLINICAL, HEMATOLOGICAL, CHEMICAL AND SEROLOGICAL STUDIES.静脉注射源自伤寒杆菌的有毒抗原物质对人体产生的影响：临床、血液学、化学及血清学研究。
J Clin Invest. 1942 Sep;21(5):589-99. doi: 10.1172/JCI101337.
2
MECHANISMS OF ENDOTOXIN TOLERANCE. 3. THE REFRACTORY STATE DURING CONTINUOUS INTRAVENOUS INFUSIONS OF ENDOTOXIN.内毒素耐受的机制。3. 持续静脉输注内毒素期间的不应状态。
J Exp Med. 1965 Jun 1;121(6):911-33. doi: 10.1084/jem.121.6.911.
3
Bacterial endotoxins: chemical structure, biological activity and role in septicaemia.细菌内毒素：化学结构、生物活性及在败血症中的作用
Scand J Infect Dis Suppl. 1982;31:8-21.
4
Purification and structural determination of nontoxic lipid A obtained from the lipopolysaccharide of Salmonella typhimurium.从鼠伤寒沙门氏菌脂多糖中获得的无毒脂质A的纯化及结构测定
J Biol Chem. 1982 Oct 10;257(19):11808-15.
5
Beneficial modification of the endotoxin molecule.内毒素分子的有益修饰
J Biol Response Mod. 1984;3(1):1-9.
6
Structural studies on the non-toxic lipid A from Rhodopseudomonas sphaeroides ATCC 17023.球形红假单胞菌ATCC 17023无毒脂多糖A的结构研究
Eur J Biochem. 1983 Oct 17;136(1):195-200. doi: 10.1111/j.1432-1033.1983.tb07726.x.
7
Nontoxic lipopolysaccharide from Rhodopseudomonas sphaeroides ATCC 17023.来自球形红假单胞菌ATCC 17023的无毒脂多糖。
J Bacteriol. 1983 Jul;155(1):153-8. doi: 10.1128/jb.155.1.153-158.1983.
8
Influence of fine structure of lipid A on Limulus amebocyte lysate clotting and toxic activities.脂多糖A的精细结构对鲎试剂凝血及毒性活性的影响。
Infect Immun. 1984 Aug;45(2):350-5. doi: 10.1128/iai.45.2.350-355.1984.
9
Position of ester groups in the lipid A backbone of lipopolysaccharides obtained from Salmonella typhimurium.从鼠伤寒沙门氏菌获得的脂多糖的脂质A主链中酯基团的位置。
J Biol Chem. 1983 Nov 10;258(21):12947-51.
10
A new method for the extraction of R lipopolysaccharides.一种提取R脂多糖的新方法。
Eur J Biochem. 1969 Jun;9(2):245-9. doi: 10.1111/j.1432-1033.1969.tb00601.x.

球形红假单胞菌脂多糖A衍生物可阻断光滑型脂多糖和单磷酰脂A在体外诱导肿瘤坏死因子和内毒素耐受。

Rhodopseudomonas sphaeroides lipid A derivatives block in vitro induction of tumor necrosis factor and endotoxin tolerance by smooth lipopolysaccharide and monophosphoryl lipid A.

作者信息

Henricson B E, Perera P Y, Qureshi N, Takayama K, Vogel S N

机构信息

Department of Microbiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814.

出版信息

Infect Immun. 1992 Oct;60(10):4285-90. doi: 10.1128/iai.60.10.4285-4290.1992.

DOI:10.1128/iai.60.10.4285-4290.1992
PMID:1398939
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC257464/
Abstract

Rhodopseudomonas (Rhodobacter) sphaeroides diphosphoryl lipid A is a relatively inert species of lipid A but has been shown to antagonize the effects of toxic lipopolysaccharide (LPS) both in vivo and in vitro. The antagonist and its monophosphoryl derivative were examined for the ability to block tumor necrosis factor synthesis and reverse tolerance induction in vitro in macrophage cultures stimulated with bioactive preparations of smooth LPS, rough LPS, diphosphoryl lipid A, and monophosphoryl lipid A. Inhibition of agonist activity and reversal of tolerance by these novel penta-acylated lipid A antagonists provides new insight into macrophage-LPS interactions.

摘要

球形红假单胞菌（红杆菌属）二磷酸化脂多糖A是一种相对惰性的脂多糖A，但已证明其在体内和体外均能拮抗有毒脂多糖（LPS）的作用。研究了该拮抗剂及其单磷酸化衍生物在体外巨噬细胞培养物中阻断肿瘤坏死因子合成以及逆转由光滑LPS、粗糙LPS、二磷酸化脂多糖A和单磷酸化脂多糖A的生物活性制剂刺激所诱导的耐受性的能力。这些新型五酰化脂多糖A拮抗剂对激动剂活性的抑制和耐受性的逆转，为巨噬细胞-LPS相互作用提供了新的见解。