Eisner A, Klein M L, Zilis J D, Watkins M D
Devers Eye Institute, Portland, Oregon.
Invest Ophthalmol Vis Sci. 1992 Oct;33(11):3091-102.
The eyes of 47 subjects with exudative age-related macular degeneration in the fellow eye were tested with a battery of visual function tests at baseline and followed for at least 18 mo. Fundus photographs also were obtained at baseline. These photographs were used to verify the absence of exudative lesions in the 47 eyes tested. Functional and funduscopic baseline data each were compared against outcome data obtained typically at 18 mo. The baseline data were analyzed for their ability to distinguish eyes that had developed detectable exudative age-related macular degeneration from eyes that had not. Eyes with relatively slow foveal dark adaptation rates despite low foveal quantum absorption capabilities (as inferred from the effects of test area on the Rayleigh color match) were especially likely to develop subretinal neovascularization. The resulting sensitivity/specificity and odds ratios were comparable to those of the most effective funduscopic risk indicators. Low S (blue) cone-mediated sensitivity also was associated with an exudative outcome.
对47例对侧眼患有渗出性年龄相关性黄斑变性的受试者的眼睛进行了一系列视觉功能测试，在基线时进行测试，并随访至少18个月。在基线时也获取了眼底照片。这些照片用于确认所测试的47只眼中不存在渗出性病变。将功能和眼底镜检查的基线数据分别与通常在18个月时获得的结果数据进行比较。分析基线数据区分已发生可检测到的渗出性年龄相关性黄斑变性的眼睛和未发生的眼睛的能力。尽管中央凹量子吸收能力较低（从测试区域对瑞利颜色匹配的影响推断），但中央凹暗适应率相对较慢的眼睛尤其容易发生视网膜下新生血管形成。由此产生的敏感性/特异性和优势比与最有效的眼底风险指标相当。低S（蓝色）视锥细胞介导的敏感性也与渗出性结果相关。
