Yang R, Sanghvi N T, Rescorla F J, Galliani C A, Fry F J, Griffith S L, Grosfeld J L
Department of Surgery, Indiana University School of Medicine, Indianapolis.
Invest Radiol. 1992 Oct;27(10):796-803. doi: 10.1097/00004424-199210000-00009.
High-intensity focused ultrasound (HIFU) is the only radiation beam that can remotely destroy deep-seated tissue targets without causing damage to the intervening tissues. This study evaluates the ability of sonography-guided HIFU to extracorporeally induce liver ablation in a rabbit model.
Under sonographic guidance, the HIFU beam was transcutaneously focused at the target tissue in the liver through a subcostal approach. A computer controlled the HIFU exposure and transducer movement to destroy a preselected tissue volume. Simultaneous sonography monitored the tissue response. Ten insonated rabbits were killed from days 0 to 10, and the liver and intervening tissues were examined histologically.
A sharply demarcated sonolesion of coagulation necrosis was produced in the liver in 9 of 10 animals. No damage was found in the intervening tissues (n = 6) when adequate acoustic coupling and proper beam path was applied.
Sonography-guided HIFU might be a potential new modality for extracorporeal inducement of liver cancer ablation without resorting to laparatomy.
高强度聚焦超声（HIFU）是唯一一种能够远程破坏深部组织靶点而不损伤中间组织的辐射束。本研究评估超声引导下HIFU在兔模型中体外诱导肝脏消融的能力。
在超声引导下，通过肋下途径将HIFU束经皮聚焦于肝脏的靶组织。计算机控制HIFU暴露和换能器移动以破坏预选的组织体积。同步超声监测组织反应。在第0天至第10天处死10只接受超声照射的兔子，对肝脏及中间组织进行组织学检查。
10只动物中有9只在肝脏产生了边界清晰的凝固性坏死超声损伤灶。当采用适当的声耦合和正确的束路径时，中间组织未发现损伤（n = 6）。
超声引导下的HIFU可能是一种无需开腹即可体外诱导肝癌消融的潜在新方法。
