Yang R, Kopecky K K, Rescorla F J, Galliani C A, Wu E X, Grosfeld J L
Department of Surgery, Indiana University School of Medicine, Indianapolis.
Invest Radiol. 1993 Sep;28(9):796-801.
The authors have previously demonstrated the ability of high-intensity focused ultrasound (HIFU) to extracorporeally induce selective tissue destruction in the liver without causing damage to the intervening abdominal wall. The potential usefulness of HIFU as a noninvasive therapy for liver cancer has been suggested. This study observes sonographic and computed tomography (CT) characteristics of HIFU-ablated liver tissue in an attempt to assess the possibility of using these imaging methods to monitor the therapeutic results.
A sonoablated lesion was induced in the liver in each of 20 rabbits with a HIFU therapeutic system. Sequential imaging of the hepatic sonolesions with sonography and CT was performed up to 8 days after treatment, and the imaging patterns were correlated with the histopathology.
Hepatic sonoablated tissue could be clearly visualized by sonography as a hypoechoic lesion. On contrast-enhanced CT, the sonolesions were depicted as nonenhanced low-density regions. There was good correlation among the sizes of sonography- and CT-depicted lesions and pathologic specimens.
In this model, sonography and contrast-enhanced CT were useful imaging modalities for monitoring sonolesion evolution after HIFU treatment.
作者之前已证明高强度聚焦超声（HIFU）能够在体外诱导肝脏组织发生选择性破坏，而不会对中间的腹壁造成损伤。有人提出HIFU作为一种肝癌无创治疗方法的潜在实用性。本研究观察HIFU消融肝脏组织的超声和计算机断层扫描（CT）特征，试图评估使用这些成像方法监测治疗效果的可能性。
使用HIFU治疗系统在20只兔子的肝脏中分别诱导出一个超声消融病灶。在治疗后长达8天的时间里，对肝脏超声病灶进行超声和CT的连续成像，并将成像模式与组织病理学进行关联。
肝脏超声消融组织在超声检查中可清晰显示为低回声病灶。在增强CT上，超声病灶表现为无强化的低密度区域。超声和CT所显示病灶的大小与病理标本之间存在良好的相关性。
在该模型中，超声和增强CT是监测HIFU治疗后超声病灶演变的有用成像方式。
