Beckham J C, Krug L M, Penzien D B, Johnson C A, Mosley T H, Meeks G R, Pbert L A, Prather R C
Department of Psychiatry, Duke University Medical Center, Durham, NC.
Headache. 1992 Jun;32(6):292-7. doi: 10.1111/j.1526-4610.1992.hed3206292.x.
Fourteen female volunteers who met diagnostic criteria for migraine headache monitored their headache activity and menstrual distress symptoms for one menstrual cycle. Serum estradiol and progesterone levels, and menstrual distress measures were collected at four points of the menstrual cycle: menstrual, ovulatory, luteal and premenstrual. Results indicated that one patient (7.1%) had menstrual migraine, 10 patients (71.4%) had menstrually-related headache and 3 (21.4%) had migraine headache unrelated to their menstrual cycle: subsequent analyses were conducted with the first two groups. Headache activity for the sample was highest during the premenstrual phase. Headache activity during the luteal and premenstrual phases was related to luteal phase progesterone levels. Menstrual distress was highest during the menstrual and premenstrual phases of the cycle, and these symptoms were related to higher estradiol levels, higher estradiol/progesterone ratios, and increased headache activity. These results indicated that for women with menstrual migraine or menstrually-related migraine, luteal progesterone and estradiol and the estradiol/progesterone ratio may be significantly related to menstrual distress during the premenstrual phase of the cycle. The estradiol/progesterone ratio was not more related to headache or menstrual distress than either of these ovarian hormones alone. Suggestions for future research in this area are offered.
14名符合偏头痛诊断标准的女性志愿者在一个月经周期内监测了她们的头痛活动和经前不适症状。在月经周期的四个时间点收集血清雌二醇和孕酮水平以及经前不适指标：月经期、排卵期、黄体期和经前期。结果表明，1名患者（7.1%）患有经期偏头痛，10名患者（71.4%）患有与月经相关的头痛，3名患者（21.4%）患有与月经周期无关的偏头痛：随后对前两组进行了分析。样本的头痛活动在经前期最高。黄体期和经前期的头痛活动与黄体期孕酮水平有关。经前不适在月经周期的月经期和经前期最高，这些症状与较高的雌二醇水平、较高的雌二醇/孕酮比值以及增加的头痛活动有关。这些结果表明，对于患有经期偏头痛或与月经相关偏头痛的女性，黄体期孕酮和雌二醇以及雌二醇/孕酮比值可能与月经周期经前期的经前不适显著相关。雌二醇/孕酮比值与头痛或经前不适的相关性并不比单独的这两种卵巢激素中的任何一种更强。本文还提供了该领域未来研究的建议。
