用盐酸大观霉素（卓青）治疗单纯性淋病。
Treatment of uncomplicated gonorrhoea with spectinomycin hydrochloride (Trobicin).
作者信息
Porter I A, Rutherford H W
出版信息
Br J Vener Dis. 1977 Apr;53(2):115-7. doi: 10.1136/sti.53.2.115.
Abstract
110 patients with uncomplicated gonococcal urethritis were treated with 2 g spectinomycin (Trobicin) intramuscularly. Seventy-five patients were available for follow-up and there was only one treatment failure, giving a cure rate of 98-6%. Of the 99 gonococcal isolates, 59 were sensitive to 5 microng/ml of spectinomycin or less and 40 were sensitive to 10 microng/ml. In a small sample of patients 2 g spectinomycin intramuscularly produced a serum concentration averaging 100 microng/ml after one hour.
摘要
110例无并发症的淋菌性尿道炎患者接受了2克壮观霉素（淋必治）肌肉注射治疗。75例患者可供随访，仅1例治疗失败，治愈率为98.6%。在99株淋球菌分离株中，59株对5微克/毫升或更低浓度的壮观霉素敏感，40株对10微克/毫升敏感。在一小部分患者中，2克壮观霉素肌肉注射1小时后血清浓度平均为100微克/毫升。
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本文引用的文献
1
Treatment of gonorrhoea with actinospectacin.用壮观霉素治疗淋病。
Br J Vener Dis. 1962 Jun;38(2):60-3. doi: 10.1136/sti.38.2.60.
2
ACTINOSPECTACIN (TROBICIN) IN THE TREATMENT OF GONORRHOEA.壮观霉素（淋必治）治疗淋病
Acta Derm Venereol. 1963;43:399-404.
3
Nature and extent of penicillin side-reactions, with particular reference to fatalities from anaphylactic shock.青霉素副作用的性质与程度，尤其涉及过敏性休克致死情况。
Bull World Health Organ. 1968;38(2):159-88.
4
Spectinomycin: minimum inhibitory concentrations for Neisseria gonorrhoeae.壮观霉素：淋病奈瑟菌的最低抑菌浓度
Br J Vener Dis. 1974 Aug;50(4):289-90. doi: 10.1136/sti.50.4.289.
5
Spectinomycin in the treatment of gonorrhoea in males.壮观霉素治疗男性淋病。
Br J Vener Dis. 1974 Aug;50(4):294-7. doi: 10.1136/sti.50.4.294.
6
Spectinomycin hydrochloride in the treatment of uncomplicated gonorrhoea in males and females.盐酸大观霉素治疗男性和女性单纯性淋病。
Br J Vener Dis. 1974 Aug;50(4):291-3. doi: 10.1136/sti.50.4.291.
7
Treatment of gonorrhoea with spectinomycin hydrochloride.用盐酸大观霉素治疗淋病。
Br J Vener Dis. 1973 Feb;49(1):60-1. doi: 10.1136/sti.49.1.60.
8
Spectinomycin hydrochloride (Trobicin) in the treatment of gonorrhoea. Observation of resistant strains of Neisseria gonorrhoeae.盐酸大观霉素（卓青）治疗淋病。淋病奈瑟菌耐药菌株的观察。
Br J Vener Dis. 1973 Feb;49(1):54-9. doi: 10.1136/sti.49.1.54.
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