Guerin S B, Schmidt J J, Kulik J E, Golitz L E
Denver General Hospital, Colorado 80204.
J Cutan Pathol. 1992 Jun;19(3):207-11. doi: 10.1111/j.1600-0560.1992.tb01660.x.
The eosinophilia-myalgia syndrome (EMS) associated with the ingestion of L-tryptophan (LT) containing products has recently been recognized in the United States. We report the histologic features of the cutaneous scleroderma-like changes in four patients. All of the patients met the Center for Disease Control criteria for EMS and had a history of LT ingestion. Skin biopsies showed increased dermal mucin and dermal sclerosis, with trapping of adnexal structures. There are clinical and histologic similarities between EMS, scleroderma, the toxic oil syndrome, and fasciitis with eosinophils.
最近在美国已认识到与摄入含L - 色氨酸（LT）产品相关的嗜酸性粒细胞增多性肌痛综合征（EMS）。我们报告了4例患者皮肤硬皮病样改变的组织学特征。所有患者均符合疾病控制中心的EMS标准，并有摄入LT的病史。皮肤活检显示真皮粘蛋白增加和真皮硬化，伴有附属器结构被困。EMS、硬皮病、中毒性油综合征和嗜酸性粒细胞性筋膜炎在临床和组织学上存在相似之处。
