Eskenasy A
Morphol Embryol (Bucur). 1977 Jan-Mar;23(1):57-65.
The influence of homologous pulmonary proteins on the lung tissue reactivity was experimentally and immunomorphologically analysed in rabbits: a. in the development of specific sensitized substrate; b. by the challenge of hypersensitivity reactions: and c. by the evaluation of the development of an experimental lung tuberculosis at the level of the sensitized lung. Morphometrical methods were used. The immunomorphological analysis pointed out the importance of the increase of pyroninophilic and plasma cells and of eosinocytes in the lung tissue sensitized to homologous proteins included in the complete Freund adjuvant, the specificity and peculiarities (frequency of plasmocytosis and necrosis) of hypersensitivity reactions intratracheally and intravenously challenged with the homologous pulmonary proteins at the level of the sensitized lung, as well as the severe evolution of the experimental lung tuberculosis by comparison with that developing in a lung substrate sensitized without homologous pulmonary proteins or unsensitized. These results provided data for the influence exerted on the lung substrate by the pulmonary proteins which are released during the evolution of lugn processes and could act as autoantigens in the framework of an autoaggressive pathogenic component of chronic diseases.
通过实验和免疫形态学方法，对家兔同源肺蛋白对肺组织反应性的影响进行了分析：a. 在特异性致敏底物的形成过程中；b. 通过超敏反应激发；c. 通过评估致敏肺水平上实验性肺结核的发展情况。采用了形态计量学方法。免疫形态学分析指出，在含有完全弗氏佐剂的同源蛋白致敏的肺组织中，嗜派洛宁细胞、浆细胞和嗜酸性粒细胞增多的重要性，在致敏肺水平经气管内和静脉内用同源肺蛋白激发的超敏反应的特异性和特点（浆细胞增多症和坏死的频率），以及与在未用同源肺蛋白致敏或未致敏的肺底物中发展的实验性肺结核相比，其严重的发展情况。这些结果为肺部疾病演变过程中释放的肺蛋白对肺底物的影响提供了数据，这些肺蛋白在慢性疾病的自身攻击性致病成分框架内可能作为自身抗原起作用。
