Baker J D, Halperin S A, Edwards K, Miller B, Decker M, Stephens D
Department of Pediatrics, Dalhousie University, Halifax, Nova Scotia, Canada.
J Pediatr. 1992 Oct;121(4):523-7. doi: 10.1016/s0022-3476(05)81138-2.
Because of apparent differences in the incidence and epidemiology of pertussis in the United States and Canada, we measured the antibody response to four Bordetella pertussis antigens and to a whole-bacteria preparation in children immunized with American and Canadian whole-cell pertussis vaccines. All infants received combined pertussis, tetanus, and diphtheria vaccines from one of two American manufacturers or a single Canadian manufacturer. The Canadian children received either oral poliomyelitis vaccine, inactivated poliomyelitis vaccine as a separate injection, or a product that combined inactivated poliomyelitis vaccine with diphtheria, tetanus, and pertussis components. The Canadian trivalent diphtheria, tetanus, and pertussis vaccine given with oral poliovirus vaccine induced lower anti-pertussis toxin antibody titers than did the American vaccines (p < or = to 0.05) but higher antifimbriae and anti-69-kilodalton outer-membrane protein (pertactin) antibody titers (p < or = to 0.02). Canadian children immunized with inactivated poliomyelitis vaccine either as a separate injection or as a combined diphtheria, tetanus, and pertussis vaccine had consistently lower pertussis antibody titers than did those who received oral poliomyelitis vaccine (p < or = 0.001). We conclude that there is a wide range of antibody responses to B. pertussis antigens after immunization with various whole-cell pertussis vaccines, and that these responses may be influenced by concurrent administration of other vaccines.
由于美国和加拿大百日咳的发病率及流行病学情况存在明显差异，我们检测了接种美国和加拿大全细胞百日咳疫苗的儿童对四种百日咳博德特氏菌抗原及一种全菌制剂的抗体反应。所有婴儿均接种了来自两家美国生产商之一或一家加拿大生产商的百日咳、破伤风和白喉联合疫苗。加拿大儿童接种的是口服脊髓灰质炎疫苗、单独注射的灭活脊髓灰质炎疫苗，或是一种将灭活脊髓灰质炎疫苗与白喉、破伤风和百日咳成分相结合的产品。与口服脊髓灰质炎疫苗同时接种的加拿大三价白喉、破伤风和百日咳疫苗诱导产生的抗百日咳毒素抗体滴度低于美国疫苗（p≤0.05），但抗菌毛和抗69千道尔顿外膜蛋白（百日咳杆菌粘附素）抗体滴度更高（p≤0.02）。单独注射灭活脊髓灰质炎疫苗或接种与白喉、破伤风和百日咳联合疫苗的加拿大儿童，其百日咳抗体滴度始终低于接种口服脊髓灰质炎疫苗的儿童（p≤0.001）。我们得出结论，接种各种全细胞百日咳疫苗后，对百日咳博德特氏菌抗原的抗体反应范围广泛，并且这些反应可能受到同时接种其他疫苗的影响。
