Glorieux J, Dussault J, Van Vliet G
Department of Pediatrics, Université de Montréal, Quebec, Canada.
J Pediatr. 1992 Oct;121(4):581-4. doi: 10.1016/s0022-3476(05)81150-3.
Twenty-seven patients with congenital hypothyroidism diagnosed by neonatal screening were examined at the age of 12 years. The 12 patients with severe hypothyroidism at diagnosis (thyroxine < 2 micrograms/dl (< 26 nmol/L), and area-of-the-knee epiphyses < 0.05 cm2 had a lower IQ than the 15 patients with less severe hypothyroidism (mean +/- SD, 89 +/- 17 vs 104 +/- 10; p < 0.007). Comparisons of patients and siblings confirm that this difference was due to the severity of hypothyroidism.
对27名经新生儿筛查确诊为先天性甲状腺功能减退症的患者在12岁时进行了检查。诊断时患有严重甲状腺功能减退症（甲状腺素<2微克/分升（<26纳摩尔/升）且膝关节骨骺面积<0.05平方厘米）的12名患者的智商低于15名甲状腺功能减退症较轻的患者（均值±标准差，89±17 vs 104±10；p<0.007）。患者与兄弟姐妹的比较证实，这种差异是由于甲状腺功能减退症的严重程度所致。
