Simons W F, Fuggle P W, Grant D B, Smith I
MRC Register of Children with Congenital Hypothyroidism, Institute of Child Health, London.
Arch Dis Child. 1994 Sep;71(3):232-4. doi: 10.1136/adc.71.3.232.
Fifty nine children born between 1978 and 1981 with congenital hypothyroidism detected by neonatal screening were assessed at 10 years using the Wechsler intelligence scale for children, together with 59 matched classroom controls. Thirty one children with severe hypothyroidism who had pretreatment plasma thyroxine concentrations of 40 nmol/l or less had a mean (SD) full scale IQ score of 104.7 (15.1), compared with a mean (SD) score of 114.6 (16.3) for the 28 less severely affected children who had pretreatment thyroxine levels greater than 40 nmol/l, and mean (SD) scores of 114.5 (12.8) and 114.8 (13.8) respectively for the 31 and 28 control children. In the hypothyroid children the IQ scores at 10 years were closely related to the IQ scores at 5 years and at 3 years. It is concluded that the deficit in IQ score found at 3 and 5 years in children with severe hypothyroidism is still evident at the age of 10 years.
对1978年至1981年间出生、通过新生儿筛查确诊为先天性甲状腺功能减退症的59名儿童，在其10岁时使用韦氏儿童智力量表进行评估，并与59名相匹配的班级对照儿童进行比较。31名重度甲状腺功能减退症患儿，其治疗前血浆甲状腺素浓度为40 nmol/l或更低，其平均（标准差）全量表智商得分为104.7（15.1）；相比之下，28名病情较轻、治疗前甲状腺素水平高于40 nmol/l的患儿，平均（标准差）得分为114.6（16.3），31名和28名对照儿童的平均（标准差）得分分别为114.5（12.8）和114.8（13.8）。在甲状腺功能减退症患儿中，10岁时的智商得分与5岁和3岁时的智商得分密切相关。研究得出结论，重度甲状腺功能减退症患儿在3岁和5岁时发现的智商缺陷在10岁时仍然明显。
