KRNJEVIC K, PHILLIS J W
Br J Pharmacol Chemother. 1963 Jun;20(3):471-90. doi: 10.1111/j.1476-5381.1963.tb01484.x.
A number of derivatives of tryptamine and phenethylamine, and certain other compounds, were tested on neurones in the cerebral cortex of cats by iontophoretic release from micro-pipettes. The characteristic action of many of these compounds was a depression of the neuronal discharge initiated by synaptic activity or by the application of L-glutamate; imidazolylacetic acid, dopamine, ephedrine and ergometrine were particularly effective. Catechol amines, hydroxytryptamines and imidazolylacetic acid had a relatively quick and rapidly reversible action, not unlike that of gamma-aminobutyric acid, whereas ephedrine and derivatives of lysergic acid diethylamide caused a slower and more prolonged depression of the amplitude of spikes, rather like atropine. Several compounds, including 5-hydroxytryptamine, adrenaline and ergometrine, could also excite the same neurone when larger amounts were applied. A few substances, such as dopa and methylergometrine, had a predominantly excitant action.
通过微量移液器离子电泳释放，对色胺和苯乙胺的多种衍生物以及某些其他化合物在猫大脑皮层神经元上进行了测试。这些化合物中许多的特征性作用是抑制由突触活动或应用L - 谷氨酸引发的神经元放电；咪唑基乙酸、多巴胺、麻黄碱和麦角新碱特别有效。儿茶酚胺、羟色胺和咪唑基乙酸具有相对快速且迅速可逆的作用，与γ-氨基丁酸的作用相似，而麻黄碱和麦角酸二乙酰胺衍生物引起的尖峰幅度抑制较慢且持续时间更长，类似于阿托品。包括5 - 羟色胺、肾上腺素和麦角新碱在内的几种化合物，当应用量较大时也能兴奋同一神经元。一些物质，如多巴和甲基麦角新碱，主要具有兴奋作用。
