Cabral D A, Oen K G, Petty R E
Department of Paediatrics, University of British Columbia, Vancouver, Canada.
J Rheumatol. 1992 Aug;19(8):1282-5.
Thirty-six of the 39 children originally described with the syndrome of seronegative enthesopathy and arthropathy, followed for a mean of 11 years after symptom onset, were found to have had a widely varied clinical course. Twelve of the 23 patients (52%) who originally did not have a seronegative spondyloarthropathy developed definite (6) or possible (6) seronegative spondyloarthropathies. The development of a seronegative spondyloarthropathy was associated with HLA-B27 (p = 0.0004) and the presence of arthritis (rather than arthralgia only) at the time of the original report (p = 0.05). For patients with arthritis, the development of a seronegative spondyloarthropathy was associated with arthritis onset after 5 years of age (p = 0.01).
最初被描述为血清阴性附着点病和关节病综合征的39名儿童中，36名在症状出现后平均随访了11年，发现其临床病程差异很大。最初没有血清阴性脊柱关节病的23名患者中有12名（52%）发展为明确的（6名）或可能的（6名）血清阴性脊柱关节病。血清阴性脊柱关节病的发生与HLA - B27相关（p = 0.0004），且与初次报告时存在关节炎（而非仅有关节痛）相关（p = 0.05）。对于有关节炎的患者，血清阴性脊柱关节病的发生与5岁后关节炎发作相关（p = 0.01）。
