Akpaffiong M J
College of Pharmacy and Health Sciences, Texas Southern University, Houston 77099.
J Natl Med Assoc. 1992 Sep;84(9):800-2.
Neuroleptic malignant syndrome, a rare and potentially fatal complication of antipsychotic drugs, is poorly understood. Equally poorly understood are the risk factors of neuroleptic malignant syndrome. Long-term and parenteral treatment with high doses of neuroleptic drugs are implicated as risk factors for the syndrome. Recently, attention has been drawn to the frequency of neuroleptic malignant syndrome in patients treated with a combination of haloperidol and lithium. This article reports a case in which the patient's risk factors for neuroleptic malignant syndrome included not only haloperidol and lithium but also a predisposition to substances of abuse.
抗精神病药物恶性综合征是一种罕见且可能致命的抗精神病药物并发症，目前对其了解甚少。同样鲜为人知的是抗精神病药物恶性综合征的风险因素。长期大剂量使用抗精神病药物进行非肠道治疗被认为是该综合征的风险因素。最近，联用氟哌啶醇和锂盐治疗的患者中抗精神病药物恶性综合征的发生率受到了关注。本文报告了一例患者，其抗精神病药物恶性综合征的风险因素不仅包括氟哌啶醇和锂盐，还包括药物滥用倾向。
