Kendler K S, Heath A C, Neale M C, Kessler R C, Eaves L J
Department of Psychiatry, Medical College of Virginia/Virginia Commonwealth University, Richmond 23298-0710.
JAMA. 1992 Oct 14;268(14):1877-82.
To clarify the role of genetic factors in the etiology of alcoholism in women.
Personal structured psychiatric interviews conducted by researchers "blinded" to the status of the co-twin in an epidemiologic sample of 1030 female-female twin pairs of known zygosity from the population-based Virginia Twin Registry.
Three definitions of lifetime prevalence of alcoholism based on Diagnostic and Statistical Manual of Mental Disorders, Third Edition, Revised criteria: (1) alcoholism with tolerance or dependence; (2) alcoholism with or without tolerance-dependence; and (3) alcoholism with or without tolerance-dependence or problem drinking.
Using narrow, intermediate, or broad definitions, the probandwise concordance for alcoholism was consistently higher in monozygotic than in dizygotic twin pairs. Multifactorial threshold models suggested that the heritability of liability to alcoholism in women is in the range of 50% to 60%.
The results support the hypothesis that genetic factors play a major role in the etiology of alcoholism in women. Women should be well represented in the efforts currently under way to elucidate the molecular basis of the genetic susceptibility to alcoholism.
阐明遗传因素在女性酒精中毒病因学中的作用。
研究人员对来自基于人群的弗吉尼亚双胞胎登记处的1030对已知合子性的女性双胞胎进行“盲法”个人结构化精神病学访谈。
基于《精神疾病诊断与统计手册》第三版修订标准的酒精中毒终生患病率的三种定义：（1）伴有耐受性或依赖性的酒精中毒；（2）伴有或不伴有耐受性 - 依赖性的酒精中毒；（3）伴有或不伴有耐受性 - 依赖性或问题饮酒的酒精中毒。
使用狭义、中度或广义定义，单卵双胞胎对酒精中毒的先证者一致率始终高于双卵双胞胎对。多因素阈值模型表明，女性酒精中毒易感性的遗传度在50%至60%范围内。
结果支持遗传因素在女性酒精中毒病因学中起主要作用这一假设。在目前正在进行的阐明酒精中毒遗传易感性分子基础的研究中，女性应得到充分代表。
