Carlson J H, Scott F W
Vet Pathol. 1977 Mar;14(2):173-81. doi: 10.1177/030098587701400209.
Proliferation rates of small intestinal mucosal cells of noninfected germfree and specific pathogen-free kittens were compared to the incidence of infected cells and microscopic lesions in kittens experimentally infected with panleukopenia virus. Mucosal crypt length, cells per crypt, mitotic index and villous length were greater in specific pathogen-free kittens than in germfree kittens. Crypt cells per unit length and villous length per crypt length ratio were greater in germfree kittens. The cryptal cell proliferation rate of specific pathogen-free kittens was 2.24 times that of germfree kittens. Mucosal crypt length, cell per crypt and villous length were greater in the proximal jejunum than in the midjejunum of kittens within groups. Cell proliferation rates per crypt did not differ between areas of the intestine in kittens within groups. There were more virus-infected cells and lesions in specific pathogen-free kittens than in germfree kittens. The incidence of virus-infected cells and lesions was greater in the proximal jejumum and decreased along the small intestine.
将未感染的无菌和无特定病原体小猫的小肠黏膜细胞增殖率与经实验感染泛白细胞减少症病毒的小猫中感染细胞的发生率和微观病变进行了比较。无特定病原体小猫的黏膜隐窝长度、每个隐窝的细胞数、有丝分裂指数和绒毛长度均大于无菌小猫。无菌小猫的单位长度隐窝细胞数和每个隐窝长度的绒毛长度比更大。无特定病原体小猫的隐窝细胞增殖率是无菌小猫的2.24倍。组内小猫近端空肠的黏膜隐窝长度、每个隐窝的细胞数和绒毛长度均大于空肠中部。组内小猫肠道不同部位每个隐窝的细胞增殖率无差异。无特定病原体小猫中病毒感染细胞和病变比无菌小猫更多。病毒感染细胞和病变的发生率在近端空肠更高，并沿小肠降低。
