Carlson J H, Scott F W, Duncan J R
Vet Pathol. 1977 Jan;14(1):79-88. doi: 10.1177/030098587701400110.
Germfree and specific pathogen-free cats were inoculated panleukopenia vivus. Total leucocyte counts decreased significantly in both germfree and specific pathogen-free cats. Clinical illness was not seen in any germfree cat. Specific pathogen-free cats had anorexia and slight diarrhea 5-6 days after inoculation. None of the cats died. Both germfree and specific pathogen-free cats had thymic involution. No other gross lesions were seen. Tissues for histological virus isolation and immunofluorescence studies were taken daily from days 2 through 6 after inoculation. Virus-infected cells and lesions of panleukopenia were seen in the small intestine of both germfree and specific pathogen-free cats. The incidence of virus-infected cells and lesions was greater in specific pathogen-free cats than in germfree cats.
将无菌猫和无特定病原体猫接种猫泛白细胞减少症活病毒。无菌猫和无特定病原体猫的白细胞总数均显著下降。无菌猫均未出现临床疾病。无特定病原体猫在接种后5 - 6天出现厌食和轻度腹泻。所有猫均未死亡。无菌猫和无特定病原体猫均出现胸腺萎缩。未观察到其他肉眼可见病变。在接种后第2天至第6天每天采集用于组织学病毒分离和免疫荧光研究的组织。在无菌猫和无特定病原体猫的小肠中均可见病毒感染细胞和猫泛白细胞减少症病变。无特定病原体猫中病毒感染细胞和病变的发生率高于无菌猫。
