[心肌梗死和不稳定型心绞痛患者中的心磷脂抗体]

[Cardiolipin antibodies in patients with myocardial infarction and unstable angina pectoris].

作者信息

Nasonov E L, Noeva E A, Kovalev V Iu, Dragnev A G, Lopaeva O V, Ruda M Ia

出版信息

Kardiologiia. 1992 May;32(5):32-4.

Abstract

The clinical value of IgG and IgM cardiolipin antibodies (CLa) was examined in 22 patients with myocardial infarction and 9 patients with unstable angina (UA). Higher IgG levels were observed in 41% of MI patients and 55% of UA patients. There was a significant correlation between the detection of IgG CLa in patients with a history of myocardial infarction and the presence of left ventricular intracavitary thrombosis. The levels of IgG CLa were increased in 78% of patients with history of MI and in 32% without MI history. In addition, those of IgG CLa was higher in 80% of IM patients with signs of intracavitary thrombosis and in 38% with cavitary thrombosis. The findings suggest that antibodies to cardiolipin (of IgG in particular) make contribution to the development of thrombotic events in patients with coronary atherosclerosis in the absence of autoimmune pathology.

摘要

对22例心肌梗死患者和9例不稳定型心绞痛（UA）患者检测了IgG和IgM心磷脂抗体（CLa）的临床价值。在41%的心肌梗死患者和55%的不稳定型心绞痛患者中观察到较高的IgG水平。有心肌梗死病史的患者中IgG CLa检测结果与左心室内血栓形成之间存在显著相关性。有心肌梗死病史的患者中78%的IgG CLa水平升高，无心肌梗死病史的患者中这一比例为32%。此外，有腔内血栓形成迹象的心肌梗死患者中80%的IgG CLa水平较高，有腔隙性血栓形成的患者中这一比例为38%。这些发现表明，在心磷脂抗体（尤其是IgG）在无自身免疫性病变的情况下对冠状动脉粥样硬化患者血栓形成事件的发生起作用。