Department of Periodontology, Narayana Dental College and Hospital, Nellore, Andhra Pradesh, India.
J Periodontol. 2011 Dec;82(12):1657-64. doi: 10.1902/jop.2011.110002. Epub 2011 Apr 12.
Serum anti-cardiolipin (aCL) antibodies are prevalent in patients with periodontal diseases. These increased aCL concentrations were identified to play a modulating role in cardiovascular diseases. The present study aims to explore the effect of phase I periodontal therapy on immunoglobulin (Ig)M and IgG aCL antibodies in patients with acute myocardial infarction (AMI) associated with chronic periodontitis.
A cross-sectional randomized clinical study was conducted within two groups comprising a sample size of 72 patients (n = 36 each). Group 1 had clinical features of AMI, and group 2 had clinical features of AMI associated with chronic periodontitis. After a thorough clinical and oral examination, the plaque index (PI), gingival index (GI), probing depth (PD), and clinical attachment loss (AL) were recorded. Serum sample collection by venipuncture was done for estimation of serum IgM and IgG aCL concentration by using an enzyme-linked immunosorbent assay method. In group 2, phase I periodontal therapy was performed, and clinical and biochemical parameters were reanalyzed after 1 month.
In group 2, the mean PI, GI, PD, clinical AL, and serum IgM and IgG aCL antibody levels were significantly higher than in group 1 patients. In addition, study results showed significant alterations in concentrations of serum IgM (P = 0.008) and IgG (P <0.001) aCL along with periodontal parameters after phase I periodontal therapy.
The phase I periodontal therapy altered levels of serum IgG and IgM aCL antibodies in patients with AMI associated with chronic periodontitis.
血清抗心磷脂（aCL）抗体在牙周病患者中很常见。这些增加的 aCL 浓度被认为在心血管疾病中起调节作用。本研究旨在探讨一期牙周治疗对急性心肌梗死（AMI）伴慢性牙周炎患者免疫球蛋白（Ig）M 和 IgG aCL 抗体的影响。
在两组中进行了一项横断面随机临床试验，每组样本量为 72 例患者（每组 36 例）。组 1 具有 AMI 的临床特征，组 2 具有 AMI 合并慢性牙周炎的临床特征。彻底的临床和口腔检查后，记录菌斑指数（PI）、牙龈指数（GI）、探诊深度（PD）和临床附着丧失（AL）。通过静脉穿刺采集血清样本，采用酶联免疫吸附试验法测定血清 IgM 和 IgG aCL 浓度。在组 2 中进行一期牙周治疗，治疗后 1 个月重新分析临床和生化参数。
在组 2 中，PI、GI、PD、临床 AL 以及血清 IgM 和 IgG aCL 抗体水平均显著高于组 1 患者。此外，研究结果显示，一期牙周治疗后血清 IgM（P=0.008）和 IgG（P<0.001）aCL 浓度以及牙周参数均发生显著变化。
一期牙周治疗改变了 AMI 合并慢性牙周炎患者血清 IgG 和 IgM aCL 抗体的水平。
