GUNDERSEN W B
J Bacteriol. 1963 Sep;86(3):510-6. doi: 10.1128/jb.86.3.510-516.1963.
Gundersen, Wenche B. (Oslo University, Oslo, Norway). New type of streptomycin resistance resulting from action of the episomelike mutator factor in Escherichia coli. J. Bacteriol. 86:510-516. 1963.-Analyses have been performed to elucidate the genetic nature of the streptomycin resistance that results from the action of the previously described episomelike mutator factor in Escherichia coli. This streptomycin resistance has been found to differ from ordinary one-step streptomycin resistance. The new type of streptomycin resistance, "mutator resistance," can be lost, either spontaneously or by treatment with ultraviolet light and acriflavine. It is more stable in a K-12 strain than in the original E. coli strain 635. Mutator resistance segregates like a chromosomal marker in genetic crosses, and is located near the ordinary streptomycin locus. The locus for mutator resistance is distinct from that of ordinary streptomycin resistance, apparently located further toward the threonine region. Mutator resistance, unlike ordinary one-step streptomycin resistance, appears as a dominant character. The possibilities of its being a suppressor or regulator mutation are discussed.
贡德森，温切·B.（挪威奥斯陆大学，奥斯陆）。大肠杆菌中类附加体突变因子作用导致的新型链霉素抗性。《细菌学杂志》86:510 - 516。1963年。——已进行分析以阐明大肠杆菌中先前描述的类附加体突变因子作用所导致的链霉素抗性的遗传本质。已发现这种链霉素抗性不同于普通的一步式链霉素抗性。新型链霉素抗性，即“突变因子抗性”，可自发丧失，或经紫外线和吖啶黄处理后丧失。它在K - 12菌株中比在原始大肠杆菌菌株635中更稳定。在遗传杂交中，突变因子抗性像染色体标记一样分离，且位于普通链霉素基因座附近。突变因子抗性基因座与普通链霉素抗性基因座不同，显然更靠近苏氨酸区域。与普通的一步式链霉素抗性不同，突变因子抗性表现为显性性状。文中讨论了其作为抑制或调节突变的可能性。
