GALE G R, MCLAIN H H
J Bacteriol. 1963 Oct;86(4):749-56. doi: 10.1128/jb.86.4.749-756.1963.
Gale, Glen R. (Veterans Administration Hospital, Durham, N.C.) and Helen H. McLain. Effect of ethambutol on cytology of Mycobacterium smegmatis. J. Bacteriol. 86:749-756. 1963.-Electron microscopy showed the effects of the antimycobacterial drug, ethambutol [d-2,2'-(ethylenediimino)-di-1-butanol], on the cytology of Mycobacterium smegmatis. After 10 hr of exposure to the drug, cells no longer contained material which, in control cells, was closely associated with cellular division, possibly genetic substance. No marked changes were observed in other cellular structures. It was concluded that the drug may block one or more steps in the synthesis of pentose nucleic acid or deoxypentose nucleic acid, ultimately causing cessation of cellular division and loss of viability. These cytological findings were compatible with results of other investigators on the mode of action of this drug.
盖尔，格伦·R.（北卡罗来纳州达勒姆退伍军人管理局医院）和海伦·H.麦克莱恩。乙胺丁醇对耻垢分枝杆菌细胞学的影响。《细菌学杂志》86:749 - 756。1963年。——电子显微镜显示了抗分枝杆菌药物乙胺丁醇[d - 2,2' -（乙二胺基）-二-1-丁醇]对耻垢分枝杆菌细胞学的影响。在接触该药物10小时后，细胞不再含有在对照细胞中与细胞分裂密切相关的物质，可能是遗传物质。在其他细胞结构中未观察到明显变化。得出的结论是，该药物可能阻断戊糖核酸或脱氧戊糖核酸合成中的一个或多个步骤，最终导致细胞分裂停止和活力丧失。这些细胞学发现与其他研究者关于该药物作用方式的结果一致。
