抗结核和抗麻风药物对分枝杆菌噬菌体D29生长的影响。
Effects of antituberculosis and antileprosy drugs on mycobacteriophage D29 growth.
作者信息
David H L, Clavel S, Clement F, Moniz-Pereira J
出版信息
Antimicrob Agents Chemother. 1980 Aug;18(2):357-9. doi: 10.1128/AAC.18.2.357.
Abstract
The minimal inhibitory concentrations of antituberculosis and antileprosy drugs were determined for Mycobacterium aurum. The concentrations that reduced the final yield of bacteriophage D29R1 by 50% and the time during the replication cycle at which the drugs completely inhibited phage production were estimated. THe 50% inhibitory concentration/minimal inhibitory concentration ratios were close to 1.0 for clofazimine, colistin, rifampin, and streptomycin; these ratios were high for dapsone (diaminodiphenylsulfone) and isoniazid. Ethambutol (minimal inhibitory concentration, 1.0 micrograms/ml) was without effect on viral growth.
摘要
测定了抗结核和抗麻风药物对金分枝杆菌的最低抑菌浓度。估算了使噬菌体D29R1最终产量降低50%的浓度以及药物在复制周期中完全抑制噬菌体产生的时间。氯法齐明、黏菌素、利福平和链霉素的50%抑制浓度/最低抑菌浓度比值接近1.0；氨苯砜（二氨二苯砜）和异烟肼的这些比值较高。乙胺丁醇（最低抑菌浓度为1.0微克/毫升）对病毒生长无影响。
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