Wendt-Gallitelli M F, Jacob R
Basic Res Cardiol. 1977 Mar-Jun;72(2-3):209-13. doi: 10.1007/BF01906363.
In Goldblatt rats, electron microscopic investigations of morphological changes in heart tissue during the compensatroy stage of pressure induced cardiac hypertrophy were performed. Myocardial cellular size enlarged considerably within the first 4 weeks after renal artery coarctation. An enlargement of the T-tubular system is particularly striking. The ratio of myofibril volume to total cell volume is significantly increased from the 4th-24th week and can at least partially explain a rise in developed tension which occurs in spite of a frequent disarrangement of myofibrils. In later stages severe changes in the vessel walls take place and there is an augmentation of connective tissue which impairs a correlation between myocardial cell alterations and mechanical parameters.
在戈德布拉特大鼠中，对压力诱导性心肌肥大代偿期心脏组织的形态学变化进行了电子显微镜研究。肾动脉缩窄后的前4周内，心肌细胞大小显著增大。T小管系统的扩大尤为显著。从第4周到第24周，肌原纤维体积与总细胞体积之比显著增加，这至少可以部分解释尽管肌原纤维频繁排列紊乱但仍出现的舒张张力升高现象。在后期，血管壁发生严重变化，结缔组织增加，这损害了心肌细胞改变与力学参数之间的相关性。
