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脑积液与多发性硬化症的发病机制

Fluids of the brain and the pathogenesis of MS.

作者信息

Thompson E J, Zeman A

机构信息

Department of Neurochemistry, Institute of Neurology, London.

出版信息

Neurochem Res. 1992 Sep;17(9):901-5. doi: 10.1007/BF00993266.

DOI:10.1007/BF00993266
PMID:1407277
Abstract

The plaques of multiple sclerosis are generally thought to spread outwards from central veins. We propose that periventricular plaques in the cerebral hemispheres, and superficial plaques in the brain stem and spinal cord, point to the importance of demyelinating factors in the cerebrospinal fluid.

摘要

多发性硬化症的斑块通常被认为是从中央静脉向外扩散的。我们提出,大脑半球的脑室周围斑块以及脑干和脊髓的浅表斑块表明脑脊液中脱髓鞘因子的重要性。

相似文献

1
Fluids of the brain and the pathogenesis of MS.脑积液与多发性硬化症的发病机制
Neurochem Res. 1992 Sep;17(9):901-5. doi: 10.1007/BF00993266.
2
Myelopathy patients studied with magnetic resonance for multiple sclerosis plaques.对患有脊髓病的患者进行磁共振成像研究以检测多发性硬化斑块。
Acta Neurol Scand. 1987 Oct;76(4):272-7. doi: 10.1111/j.1600-0404.1987.tb03580.x.
3
High resolution proton MR spectroscopy of cerebrospinal fluid in MS patients. Comparison with biochemical changes in demyelinating plaques.多发性硬化症患者脑脊液的高分辨率质子磁共振波谱分析。与脱髓鞘斑块生化变化的比较。
J Neurol Sci. 1996 Dec;144(1-2):182-90. doi: 10.1016/s0022-510x(96)00224-9.
4
Magnetic resonance demonstration of multiple sclerosis plaques in the cervical cord.颈髓多发性硬化斑块的磁共振成像显示
AJR Am J Roentgenol. 1985 Feb;144(2):381-5. doi: 10.2214/ajr.144.2.381.
5
Infrared spectroscopic characterisation of multiple sclerosis plaques in the human central nervous system.人类中枢神经系统中多发性硬化斑块的红外光谱表征
Biochim Biophys Acta. 1993 Oct 20;1182(3):333-7. doi: 10.1016/0925-4439(93)90078-f.
6
Multiple sclerosis: correlation between immunoglobulin-G in cerebrospinal fluid and brain.多发性硬化症:脑脊液中免疫球蛋白G与大脑之间的相关性
Science. 1966 Nov 25;154(3752):1044-5. doi: 10.1126/science.154.3752.1044.
7
[Acute posterior cord lesions in multiple sclerosis. An MRI study of the clinical course in 20 cases].[多发性硬化症中的急性后索病变。20例临床病程的MRI研究]
Rev Neurol (Paris). 2000 Dec;156(12):1126-35.
8
An extensive search for autoantibodies to myelin basic protein in cerebrospinal fluid of non-multiple-sclerosis patients: implications for the pathogenesis of multiple sclerosis.对非多发性硬化症患者脑脊液中髓鞘碱性蛋白自身抗体的广泛搜索:对多发性硬化症发病机制的启示
Eur Neurol. 1999;42(2):95-104. doi: 10.1159/000069418.
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Cerebrospinal Fluid Dynamics in Patients with Multiple Sclerosis: The Role of Phase-Contrast MRI in the Differential Diagnosis of Active and Chronic Disease.多发性硬化症患者的脑脊液动力学:相位对比 MRI 在活动期和慢性期疾病鉴别诊断中的作用。
Korean J Radiol. 2018 Jan-Feb;19(1):72-78. doi: 10.3348/kjr.2018.19.1.72. Epub 2018 Jan 2.
10
Induction of cell death in rat brain by a gliotoxic factor from cerebrospinal fluid in multiple sclerosis.多发性硬化症患者脑脊液中的神经胶质毒性因子可诱导大鼠脑细胞死亡
Cell Mol Biol (Noisy-le-grand). 2002 Mar;48(2):205-12.

本文引用的文献

1
The distribution of plaques in the cerebrum in multiple sclerosis.多发性硬化症中大脑内斑块的分布情况。
J Neurol Neurosurg Psychiatry. 1962 Nov;25(4):315-20. doi: 10.1136/jnnp.25.4.315.
2
The diagnostic value of the examination of the cerebrospinal fluid.脑脊液检查的诊断价值。
Postgrad Med J. 1952 Nov;28(325):587-91. doi: 10.1136/pgmj.28.325.587.
3
Bulk flow of brain interstitial fluid under normal and hyperosmolar conditions.正常和高渗条件下脑间质液的 bulk 流动。 (注:这里“bulk flow”直译为“体积流”,但在医学语境下可能不太好理解,或许结合更专业的医学知识有更准确的特定术语表述,不过仅按要求翻译就是这样)
Am J Physiol. 1980 Jan;238(1):F42-9. doi: 10.1152/ajprenal.1980.238.1.F42.
4
Periventricular lesions in multiple sclerosis: their perivenous origin and relationship to granular ependymitis.
Neuropathol Appl Neurobiol. 1987 Mar-Apr;13(2):141-52. doi: 10.1111/j.1365-2990.1987.tb00177.x.
5
Cerebrospinal fluid in multiple sclerosis: relationships between immunoglobulins, leucocytes and clinical features.多发性硬化症中的脑脊液:免疫球蛋白、白细胞与临床特征之间的关系
J Neurol. 1985;232(4):250-9. doi: 10.1007/BF00313789.
6
Blood-brain barrier damage in acute multiple sclerosis plaques. An immunocytological study.
Brain. 1991 Feb;114 ( Pt 1B):557-72. doi: 10.1093/brain/114.1.557.
7
The cervical cord in multiple sclerosis.多发性硬化症中的颈髓
Neuropathol Appl Neurobiol. 1978 Mar-Apr;4(2):151-62. doi: 10.1111/j.1365-2990.1978.tb00555.x.
8
Cerebrospinal fluid production: stimulation by cholera toxin.脑脊液生成:霍乱毒素的刺激作用
Science. 1977 May 27;196(4293):1012-3. doi: 10.1126/science.193189.