Walker R W, Thompson E J, McDonald W I
J Neurol. 1985;232(4):250-9. doi: 10.1007/BF00313789.
Cerebrospinal fluid (CSF) from 120 patients with multiple sclerosis was analyzed by polyacrylamide gel electrophoresis, as well as routine laboratory microscopy and assays of total protein and immunoglobulin G (IgG). Negative correlations were found between leucocyte counts and patient age, duration of disease and time from last clinical relapse. There was a positive correlation between the leucocyte count and amount of gammaglobulin. A correlation between gammaglobulin content and degree of disability was found. With increasing duration, the gammaglobulin concentration rose only if there was increasing disability. In terms of correlations with clinical features, differences existed depending on whether IgG was assayed immunologically or by electrophoresis and densitometry. Evidence of increased blood: CSF barrier permeability (transudation of high molecular weight proteins) was found in patients with progressive disease. The presence of oligoclonal bands was the CSF abnormality most frequently encountered.
采用聚丙烯酰胺凝胶电泳、常规实验室显微镜检查以及总蛋白和免疫球蛋白G（IgG）检测等方法，对120例多发性硬化症患者的脑脊液（CSF）进行了分析。白细胞计数与患者年龄、病程以及距上次临床复发的时间呈负相关。白细胞计数与γ球蛋白量呈正相关。发现γ球蛋白含量与残疾程度之间存在相关性。随着病程延长，只有残疾程度增加时γ球蛋白浓度才会升高。在与临床特征的相关性方面，根据IgG是通过免疫学方法还是电泳及光密度测定法进行检测，存在差异。在进行性疾病患者中发现了血脑屏障通透性增加（高分子量蛋白质渗出）的证据。寡克隆带的出现是脑脊液中最常出现的异常情况。
