Choo L P, Jackson M, Halliday W C, Mantsch H H
Institute for Biodiagnostics, National Research Council Canada, Winnipeg, Manitoba.
Biochim Biophys Acta. 1993 Oct 20;1182(3):333-7. doi: 10.1016/0925-4439(93)90078-f.
Fourier transform infrared spectroscopy has been used for the characterisation of white matter, grey matter and multiple sclerosis plaques from human central nervous system tissue. We demonstrate significant differences in the infrared spectra of the three types of tissue, which show that an infrared spectroscopic discrimination of multiple sclerosis plaques from healthy brain tissue is possible in principle. The spectral changes reveal pronounced lipid loss in plaques, consistent with the demyelinating nature of the disease. The chronic plaques studied here can also be distinguished from other non-myelinated areas of the brain, based on differences in water content.
傅里叶变换红外光谱已被用于对来自人类中枢神经系统组织的白质、灰质和多发性硬化斑块进行表征。我们证明了这三种组织的红外光谱存在显著差异，这表明原则上可以通过红外光谱鉴别多发性硬化斑块与健康脑组织。光谱变化揭示了斑块中明显的脂质损失，这与该疾病的脱髓鞘性质一致。基于含水量的差异，这里研究的慢性斑块也可以与大脑的其他无髓鞘区域区分开来。
