Lesniewska B, Nussdorfer G G, Nowak M, Malendowicz L K
Department of Histology and Embryology, University School of Medicine, Poznan, Poland.
Neuropeptides. 1992 Sep;23(1):9-13. doi: 10.1016/0143-4179(92)90003-f.
Neurotensin (NT) and vasopressin (AVP) share some similarities as far as their actions on the adrenal weight and secretion are concerned. The present study aimed to compare the in vivo chronic effect of these two peptides on the adrenal cortex of dexamethasone (Dx)-treated rats. NT or AVP were ip. infused at a rate of 2 micrograms/rat/d for 7 d. In the animals concomitantly treated with 15 micrograms Dx/100 g/d for 7 d, both NT and AVP partially prevented adrenal atrophy. AVP enhanced plasma aldosterone concentration (PAC), but not that of corticosterone (PBC). On the other hand, NT did not affect either PAC or PBC. In rats treated with 35 micrograms Dx/100 g/d for 14 d, neither NT nor AVP administered for the last 7 d exerted any effect on the adrenal weight. However, also under these conditions of profound adrenal atrophy AVP was still able to notably raise PAC, while NT was ineffective. Our findings indicate that the mechanism underlying the aldosterone secretagogue action of AVP does not require, unlike that of NT, the presence of ACTH. Moreover, in light of many recent literature data they could suggest the possibility that in vivo NT acts on the rat adrenal cortex via AVP.
就神经降压素（NT）和血管加压素（AVP）对肾上腺重量及分泌的作用而言，它们存在一些相似之处。本研究旨在比较这两种肽对接受地塞米松（Dx）治疗的大鼠肾上腺皮质的体内慢性影响。NT或AVP以2微克/大鼠/天的速率腹腔内注射，持续7天。在同时接受15微克Dx/100克/天治疗7天的动物中，NT和AVP均部分预防了肾上腺萎缩。AVP提高了血浆醛固酮浓度（PAC），但未提高皮质酮浓度（PBC）。另一方面，NT对PAC或PBC均无影响。在接受35微克Dx/100克/天治疗14天的大鼠中，在最后7天给予的NT或AVP对肾上腺重量均无任何影响。然而，即便在这种严重肾上腺萎缩的情况下，AVP仍能显著提高PAC，而NT则无效。我们的研究结果表明，与NT不同，AVP的醛固酮促分泌作用机制并不需要促肾上腺皮质激素（ACTH）的存在。此外，鉴于最近的许多文献数据，它们可能提示体内NT可能通过AVP作用于大鼠肾上腺皮质的可能性。
